{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:09:49Z","timestamp":1777424989467,"version":"3.51.4"},"reference-count":57,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1976,3,1]],"date-time":"1976-03-01T00:00:00Z","timestamp":194486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[1976,3]]},"abstract":"<jats:p>Fluorocitrate, an inhibitor of the tricarboxylic acid cycle at the aconitase reaction, produces a time and dose related neural dystrophy in the guinea pig cochlea. There is direct inhibition of succinic dehydrogenase activity but not nicotinamide adenine dinucleotide dehydrogenase and cytochrome oxidase via cytochrome c activities. The dystrophic neural changes morphologically are similar to those noted in primary neural degeneration and neural presbycusis in man. Neural degeneration in aging appears to be the result of a dissociation of biochemical reactions preventing the proper utilization of organic fuel molecules for generation of energy and direct or indirect inhibition of respiration.<\/jats:p>","DOI":"10.1177\/000348947608500202","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:29:51Z","timestamp":1412346591000},"page":"185-197","source":"Crossref","is-referenced-by-count":6,"title":["Fluorocitrate Ototoxicity"],"prefix":"10.1177","volume":"85","author":[{"given":"Gershon J.","family":"Spector","sequence":"first","affiliation":[{"name":"St. Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles D.","family":"Carr","sequence":"additional","affiliation":[{"name":"St. Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1976,3,1]]},"reference":[{"key":"bibr1-000348947608500202","volume-title":"Das Gehorogan der Werbelthiere.","author":"Retzius G","year":"1884"},{"key":"bibr2-000348947608500202","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1288\/00005537-193706000-00002","volume":"47","author":"Lorente De No R","year":"1937","journal-title":"Laryngoscope"},{"key":"bibr3-000348947608500202","volume-title":"Neural Mechanisms of the Auditory and Vestibular System.","author":"Rasmussen GL","year":"1965"},{"key":"bibr4-000348947608500202","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1288\/00005537-195112000-00002","volume":"61","author":"Fernandez CJ","year":"1952","journal-title":"Laryngoscope"},{"key":"bibr5-000348947608500202","doi-asserted-by":"publisher","DOI":"10.3109\/00016486209127336"},{"key":"bibr6-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-504250-5.50012-6"},{"key":"bibr7-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(61)80025-7"},{"key":"bibr8-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1177\/000348946107000216"},{"key":"bibr9-000348947608500202","first-page":"1","volume":"236","author":"Bredberg G","year":"1968","journal-title":"Acta Otolaryngol"},{"key":"bibr10-000348947608500202","doi-asserted-by":"publisher","DOI":"10.3109\/00016486409121399"},{"key":"bibr11-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1967.00760040601005"},{"key":"bibr12-000348947608500202","volume-title":"Discharge patterns of single fibers in the cat's auditory nerve.","author":"Kiang NY-S","year":"1965"},{"key":"bibr13-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-195306000-00001"},{"key":"bibr14-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100050465"},{"key":"bibr15-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1037\/h0062713"},{"key":"bibr16-000348947608500202","first-page":"289","volume":"20","author":"Wittmaack K","year":"1911","journal-title":"Otol Gesellsch"},{"key":"bibr17-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-195702000-00002"},{"key":"bibr18-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1964.00750040381003"},{"key":"bibr19-000348947608500202","first-page":"1","volume":"52","author":"Manasse P","year":"1906","journal-title":"Z Ohrenheilk"},{"key":"bibr20-000348947608500202","doi-asserted-by":"publisher","DOI":"10.3109\/05384916909079061"},{"key":"bibr21-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1965.00760010117010"},{"key":"bibr22-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1177\/000348947208100203"},{"key":"bibr23-000348947608500202","volume":"143","author":"Sercer A","year":"1958","journal-title":"Acta Otolaryngol"},{"key":"bibr24-000348947608500202","unstructured":"Schuknecht HF: Pathology of the Ear. Cambridge, Harvard Press, 1974, pp 65, 388\u2013403"},{"key":"bibr25-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197410000-00003"},{"key":"bibr26-000348947608500202","unstructured":"Merzenich MM, Schindler RA, Soy FA: Electrical stimulation of the acoustic nerve in man, in\n                      Proceedings of the First International Conference on Electrical Stimulation of the Acoustic Nerve as a Treatment of Profound Sensorineural Deafness in Man.\n                      San Francisco, Velo-Bind Inc, 1974"},{"key":"bibr27-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1002\/lary.5540820101"},{"key":"bibr28-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197410000-00004"},{"key":"bibr29-000348947608500202","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0026-895X(25)15204-8","volume":"6","author":"Miller RN","year":"1970","journal-title":"Mol Pharmacol"},{"key":"bibr30-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.29.1.113"},{"key":"bibr31-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.38.1.1"},{"key":"bibr32-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1177\/19.5.273"},{"key":"bibr33-000348947608500202","first-page":"183","volume-title":"Advances in Enzymology.","author":"Ochoa S","year":"1954"},{"key":"bibr34-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-299251-3.50010-0"},{"key":"bibr35-000348947608500202","first-page":"495","volume-title":"The enzymes","volume":"5","author":"Dickman SR","year":"1961","edition":"2"},{"key":"bibr36-000348947608500202","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1016\/S0021-9258(18)96082-5","volume":"242","author":"Rose IA","year":"1967","journal-title":"J Biol Chem"},{"key":"bibr37-000348947608500202","first-page":"1","volume":"2","author":"Kornberg HL","year":"1966","journal-title":"Essays Biochem"},{"key":"bibr38-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1126\/science.170.3965.1412"},{"key":"bibr39-000348947608500202","first-page":"67","volume":"20","author":"Marais JSC","year":"1944","journal-title":"Onderstepoort J Vet Res"},{"key":"bibr40-000348947608500202","first-page":"11","volume":"108","author":"Liebecq C","year":"1948","journal-title":"J Physiol"},{"key":"bibr41-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3002(49)90095-5"},{"key":"bibr42-000348947608500202","first-page":"561","author":"Martius C","year":"1949","journal-title":"Ann Chem"},{"key":"bibr43-000348947608500202","first-page":"113","volume":"18","author":"Peters RA","year":"1957","journal-title":"Adv Enzymol"},{"key":"bibr44-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1042\/bj1200345"},{"key":"bibr45-000348947608500202","first-page":"72a","volume":"35","author":"Koenig H","year":"1967","journal-title":"J Cell Biol"},{"key":"bibr46-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1971.tb11992.x"},{"key":"bibr47-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1126\/science.164.3877.310"},{"key":"bibr48-000348947608500202","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0021-9258(18)51696-3","volume":"239","author":"Fanshier DW","year":"1964","journal-title":"J Biol Chem"},{"key":"bibr49-000348947608500202","volume-title":"Citric Acid Cycle.","author":"Kun E","year":"1969"},{"key":"bibr50-000348947608500202","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/S0021-9258(18)93528-3","volume":"243","author":"Mehlman MA","year":"1968","journal-title":"J Biol Chem"},{"key":"bibr51-000348947608500202","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0026-895X(25)14843-8","volume":"3","author":"Kun E","year":"1967","journal-title":"Mol Pharmacol"},{"key":"bibr52-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(71)80205-3"},{"key":"bibr53-000348947608500202","doi-asserted-by":"publisher","DOI":"10.3109\/00016487209138926"},{"key":"bibr54-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-510150-9.50008-0"},{"key":"bibr55-000348947608500202","first-page":"53P","volume":"88","author":"Whittaker VP","year":"1963","journal-title":"Biochem J"},{"key":"bibr56-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1007\/BF00319215"},{"key":"bibr57-000348947608500202","doi-asserted-by":"publisher","DOI":"10.1007\/BF00337456"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348947608500202","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348947608500202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:28:15Z","timestamp":1777375695000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348947608500202"}},"subtitle":["A Morphologic and Cytochemical Model for Primary Neural Degeneration in the Guinea Pig Cochlea"],"short-title":[],"issued":{"date-parts":[[1976,3]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1976,3]]}},"alternative-id":["10.1177\/000348947608500202"],"URL":"https:\/\/doi.org\/10.1177\/000348947608500202","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,3]]}}}