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When administered chronically (1\u201320 mg\/kg, i.p. for 20 days), nicotine demonstrated no effect on cochlear potentials or the number of observed hair cell scars monitored 21 days after the treatment was terminated. Neither chronic nicotine treatment (1\u201320 mg\/kg, i.p. for 20 days) nor acute reserpine pretreatment (5 mg\/kg, i.p. 24 hours before) altered the hair cell damaging effects of an intense pure tone (4 kHz, 126 dB SPL, 30 min). No nicotine ototoxicity was detected by the methods used in this study.<\/jats:p>","DOI":"10.1177\/000348947608500209","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:29:51Z","timestamp":1412346591000},"page":"247-254","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Nicotine on Cochlear Function and Noise-Induced Hair Cell Loss"],"prefix":"10.1177","volume":"85","author":[{"given":"Richard P.","family":"Bobbin","sequence":"first","affiliation":[{"name":"New Orleans, Louisiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria I.","family":"Gondra","sequence":"additional","affiliation":[{"name":"New Orleans, Louisiana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1976,3,1]]},"reference":[{"key":"bibr1-000348947608500209","volume-title":"Tobacco Experimental and Clinical Studies.","author":"Larson PS","year":"1961"},{"key":"bibr2-000348947608500209","volume-title":"Tobacco Experimental and Clinical Studies","author":"Larson PS","year":"1968"},{"key":"bibr3-000348947608500209","volume-title":"Tobacco Experimental and Clinical Studies","author":"Larson PS","year":"1971"},{"key":"bibr4-000348947608500209","first-page":"96","volume":"43","author":"Shapiro SL","year":"1964","journal-title":"Eye Ear Nose Throat Mon"},{"key":"bibr5-000348947608500209","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)33285-0"},{"key":"bibr6-000348947608500209","unstructured":"Wright MI: The Pathology of Deafness. 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