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These patients lacked resistance to the normal flora of the nasopharynx and pharynx. They were accordingly treated with a mixed respiratory bacterial vaccine, administered intradermally and according to a formulated program, to improve resistance or immunity of the lymphoid tissue. These patients showed definite improvement by this method of therapy. It is suggested that the effectiveness of therapy was accomplished through the immunological process of cell-mediated immunity. The immunobiologic development of cell-mediated immunity by T thymic-dependent cells and humoral immunity by B cells is briefly discussed.<\/jats:p>","DOI":"10.1177\/000348947808700511","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:29:51Z","timestamp":1412346591000},"page":"663-669","source":"Crossref","is-referenced-by-count":0,"title":["Cyclic Pharyngeal Lymphoiditis: Immunological Considerations"],"prefix":"10.1177","volume":"87","author":[{"given":"Joseph L.","family":"Goldman","sequence":"first","affiliation":[{"name":"New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1978,9,1]]},"reference":[{"key":"bibr1-000348947808700511","volume-title":"Immunobiology","author":"Good RA","year":"1973"},{"key":"bibr2-000348947808700511","volume-title":"An ABC of Modern Immunology","author":"Holborow EJ","year":"1973","edition":"2"},{"key":"bibr3-000348947808700511","volume-title":"Lecture on the Comparative Pathology of Inflammation","author":"Metchnikoff E","year":"1968"},{"key":"bibr4-000348947808700511","volume-title":"Immunology","author":"Bellanti TA","year":"1971"},{"key":"bibr5-000348947808700511","volume-title":"Immunologic Incompetence","author":"Kagan BM","year":"1971"},{"key":"bibr6-000348947808700511","volume-title":"Surgical Immunology","author":"Munster EM","year":"1976"},{"key":"bibr7-000348947808700511","volume-title":"Essential Immunology","author":"Roitt IM","year":"1977","edition":"3"},{"key":"bibr8-000348947808700511","doi-asserted-by":"publisher","DOI":"10.1177\/000348945005900113"},{"key":"bibr9-000348947808700511","first-page":"68","volume":"58","author":"Goldman JL","year":"1954","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"bibr10-000348947808700511","doi-asserted-by":"publisher","DOI":"10.1177\/000348943504400406"},{"key":"bibr11-000348947808700511","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1937.02780420014004"},{"key":"bibr12-000348947808700511","doi-asserted-by":"publisher","DOI":"10.1084\/jem.48.1.83"},{"key":"bibr13-000348947808700511","doi-asserted-by":"publisher","DOI":"10.1084\/jem.53.4.567"},{"key":"bibr14-000348947808700511","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1977.03280250039019"},{"key":"bibr15-000348947808700511","doi-asserted-by":"publisher","DOI":"10.1084\/jem.45.4.713"},{"key":"bibr16-000348947808700511","unstructured":"Food and Drug Administration, Dept of HEW: Bacterial Vaccines and Bacterial Antigens with No US Standard of Potency, Implementation of Efficacy Review. Federal Register, Nov 8 1977, Part II."},{"key":"bibr17-000348947808700511","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0308-2261(21)00270-8","volume":"6","author":"Siegal FP","year":"1977","journal-title":"Clin Haematol"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348947808700511","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348947808700511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:30:18Z","timestamp":1777375818000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348947808700511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,9]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1978,9]]}},"alternative-id":["10.1177\/000348947808700511"],"URL":"https:\/\/doi.org\/10.1177\/000348947808700511","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,9]]}}}