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Patients that are diagnosed early respond well to drainage and ventilation of the infected middle ear combined with in vitro effective antibacterial therapy. Patients that receive prior inappropriate antibacterial therapy tend to have prolonged courses and require mastoid surgery. It is suggested that early myringotomy and bacterial cultures be performed in all patients with acute middle ear infections.<\/jats:p>","DOI":"10.1177\/000348948008900109","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:35:41Z","timestamp":1412346941000},"page":"33-36","source":"Crossref","is-referenced-by-count":13,"title":["Acute Gram-Negative Bacillary Infections of Middle Ear and Mastoid"],"prefix":"10.1177","volume":"89","author":[{"given":"Ervin","family":"Ostfeld","sequence":"first","affiliation":[{"name":"Tel-Hashomer, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethan","family":"Rubinstein","sequence":"additional","affiliation":[{"name":"Tel-Hashomer, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1980,1,1]]},"reference":[{"key":"bibr1-000348948008900109","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1967.03130210071011"},{"key":"bibr2-000348948008900109","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1968.02100010544003"},{"key":"bibr3-000348948008900109","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100071905"},{"key":"bibr4-000348948008900109","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1542\/peds.45.1.29","volume":"45","author":"Howie VM","year":"1970","journal-title":"Pediatrics"},{"key":"bibr5-000348948008900109","doi-asserted-by":"publisher","DOI":"10.3109\/00016487509121343"},{"key":"bibr6-000348948008900109","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1542\/peds.56.2.285","volume":"56","author":"Rowe DS","year":"1975","journal-title":"Pediatrics"},{"key":"bibr7-000348948008900109","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1976.02120100055008"},{"key":"bibr8-000348948008900109","unstructured":"Edwards PR, Ewing WA. 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