{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:23:20Z","timestamp":1777425800944,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1982,7,1]],"date-time":"1982-07-01T00:00:00Z","timestamp":394329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[1982,7]]},"abstract":"<jats:p>\n                    Fourteen patients with aggressive juvenile laryngeal papillomatosis were treated with systemic administration of alpha-type interferon (IFN). The initial dosage of 2 million units alpha-interferon\/m\n                    <jats:sup>2<\/jats:sup>\n                    was modified if a favorable response in the papilloma growth occurred, or if persistent drug-related side effects developed. Half of the patients showed a sustained response while on IFN, and two patients had a complete response. Persistent elevation in SGOT was the main dose-limiting toxicity, especially in infants below age seven years. All side effects subsided after the drug was discontinued. Further studies are recommended.\n                  <\/jats:p>","DOI":"10.1177\/000348948209100422","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:35:41Z","timestamp":1412346941000},"page":"431-436","source":"Crossref","is-referenced-by-count":74,"title":["Leukocyte Interferon in Patients with Juvenile Laryngeal Papillomatosis"],"prefix":"10.1177","volume":"91","author":[{"given":"Helmuth","family":"Goepfert","sequence":"first","affiliation":[{"name":"Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan U.","family":"Gutterman","sequence":"additional","affiliation":[{"name":"Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Dichtel","sequence":"additional","affiliation":[{"name":"Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy B.","family":"Sessions","sequence":"additional","affiliation":[{"name":"Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayten","family":"Cangir","sequence":"additional","affiliation":[{"name":"Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelle","family":"Sulek","sequence":"additional","affiliation":[{"name":"Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1982,7,1]]},"reference":[{"key":"bibr1-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197904000-00003"},{"key":"bibr2-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1177\/000348947007900618"},{"key":"bibr3-000348948209100422","first-page":"329","volume":"9","author":"Olofsson J","year":"1980","journal-title":"J Otolaryngol"},{"key":"bibr4-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1978.00790070051013"},{"key":"bibr5-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-196809000-00003"},{"key":"bibr6-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1177\/000348947208100605"},{"key":"bibr7-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100087156"},{"key":"bibr8-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1963.00750010621008"},{"key":"bibr9-000348948209100422","first-page":"205","volume":"64","author":"Land FT","year":"1950","journal-title":"J Laryngol Otol"},{"key":"bibr10-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1950.00700030101011"},{"key":"bibr11-000348948209100422","doi-asserted-by":"publisher","DOI":"10.3109\/00016486709128732"},{"key":"bibr12-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1177\/000348945005900225"},{"key":"bibr13-000348948209100422","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.24.11"},{"key":"bibr14-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1177\/000348948008900522"},{"key":"bibr15-000348948209100422","doi-asserted-by":"publisher","DOI":"10.3109\/00016486809120943"},{"key":"bibr16-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1002\/lary.5540891018"},{"key":"bibr17-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1177\/000348947508400508"},{"key":"bibr18-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1177\/000348947608500412"},{"key":"bibr19-000348948209100422","first-page":"572","volume":"71","author":"Rubin JA","year":"1954","journal-title":"Can Med Assoc"},{"key":"bibr20-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197307000-00013"},{"key":"bibr21-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1007\/BF00455870"},{"key":"bibr22-000348948209100422","volume-title":"Handbuch der Hals-Nasen-Ohren-Heilkundemit Einschluss der Grenzgebiete","volume":"5","author":"Thost A","year":"1926"},{"key":"bibr23-000348948209100422","first-page":"317","volume":"5","author":"Ullman EV","year":"1923","journal-title":"Acta Otolaryngol (Stockh)"},{"key":"bibr24-000348948209100422","first-page":"87","volume":"29","author":"Ishikawa K","year":"1936","journal-title":"Fukuoka Acta Med (abstr)"},{"key":"bibr25-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1007\/BF01542896"},{"key":"bibr26-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1958.00730010276002"},{"key":"bibr27-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1007\/BF01482742"},{"key":"bibr28-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1980.tb27958.x"},{"key":"bibr29-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197811000-00009"},{"key":"bibr30-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1159\/000149176"},{"key":"bibr31-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V55.6.875.875"},{"key":"bibr32-000348948209100422","first-page":"271","volume":"33","author":"Gutterman JU","year":"1981","journal-title":"Cancer Bull"},{"key":"bibr33-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197207202870305"},{"key":"bibr34-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/51.3.733"},{"key":"bibr35-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1007\/BF00996140"},{"key":"bibr36-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1981.00790420001001"},{"key":"bibr37-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197207062870104"},{"key":"bibr38-000348948209100422","first-page":"429","volume":"35","author":"Strander H","year":"1977","journal-title":"Tex Rep Biol Med"},{"key":"bibr39-000348948209100422","unstructured":"Cantell K, Hirvones S, Mogensen KE, Pyhala L. Human leukocyte interferon: Production, purification, stability and animal experiments. In Vitro 1974: 35\u20138."},{"key":"bibr40-000348948209100422","volume-title":"Interferon and interferon inducers","author":"Berg K","year":"1980"},{"key":"bibr41-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1038\/287411a0"},{"key":"bibr42-000348948209100422","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-93-3-399"},{"key":"bibr43-000348948209100422","unstructured":"Gutterman J, Fein S, Quesada J, Recombinant leukocyte A interferon; pharmacokinetics, single dose tolerance and biologic effects in cancer patients. Ann Intern Med (in press)."},{"key":"bibr44-000348948209100422","doi-asserted-by":"publisher","DOI":"10.1007\/BF00410690"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348948209100422","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348948209100422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:30:08Z","timestamp":1777375808000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348948209100422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,7]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1982,7]]}},"alternative-id":["10.1177\/000348948209100422"],"URL":"https:\/\/doi.org\/10.1177\/000348948209100422","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,7]]}}}