{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:27:02Z","timestamp":1777426022283,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1983,3,1]],"date-time":"1983-03-01T00:00:00Z","timestamp":415324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[1983,3]]},"abstract":"<jats:p>Deafness due to inner ear anomalies is rarely associated with malformations of the auricles. We describe two brothers with profound congenital sensorineural deafness, abnormal vestibular function, normal ossicles, and delayed motor development. Since the external and inner ear originate from distinctly separate structures, the embryogenesis of this malformation association is less clear than in the more common association of external and middle anomalies, where the latter two structures are derived from the first and second branchial arches. The combination of auricular and inner ear anomalies, with sparing of the middle ear structures, can be explained on the assumption that mesodermal induction is responsible for normal differentiation of both the otocyst and of the branchial arch ectoderm. A recessive mutant gene may lead to a deficiency of a mesodermal inducer substance of a target tissue receptor site. A similar mechanism may be involved in other multiple malformation syndromes, whereby a mutant gene acting during a specific period of organogenesis causes disruption of the normal induction-competence relationship.<\/jats:p>","DOI":"10.1177\/000348948309200213","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:35:41Z","timestamp":1412346941000},"page":"160-164","source":"Crossref","is-referenced-by-count":0,"title":["Mesodermal Induction Defect as a Possible Cause of Ear Malformations"],"prefix":"10.1177","volume":"92","author":[{"given":"Andrew R.","family":"Melnyk","sequence":"first","affiliation":[{"name":"Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lester","family":"Weiss","sequence":"additional","affiliation":[{"name":"Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1983,3,1]]},"reference":[{"key":"bibr1-000348948309200213","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.1.2.118"},{"key":"bibr2-000348948309200213","unstructured":"Friedman I. Pathology of the ear. Oxford: Blackwell Scientific Publications, 1974: 359\u201361, 363\u20134, 368\u20139, 371\u201380, 385\u20136."},{"key":"bibr3-000348948309200213","unstructured":"Konigsmark BW, Gorlin RJ. Genetic and metabolic deafness. Philadelphia: WB Saunders, 1976: xv\u2013xx, 56, 345\u20138, 357\u20139, 368."},{"key":"bibr4-000348948309200213","first-page":"336","volume":"1","author":"Spears GS","year":"1973","journal-title":"Clin Nephrol"},{"key":"bibr5-000348948309200213","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1542\/peds.62.4.578","volume":"62","author":"Sandra L","year":"1978","journal-title":"Pediatrics"},{"key":"bibr6-000348948309200213","first-page":"355","volume":"56","author":"Nakamura O","year":"1978","journal-title":"Med Biol"},{"key":"bibr7-000348948309200213","first-page":"599","volume":"100","author":"Spemann H","year":"1924","journal-title":"Arch Mikr Anat Entwmech"},{"key":"bibr8-000348948309200213","first-page":"55","volume":"3","author":"Michel EM","year":"1863","journal-title":"Gas M\u00e9d Strasburg"},{"key":"bibr9-000348948309200213","first-page":"31","volume-title":"Malformation syndromes. Birth defects: Original article series","author":"Karmody CS","year":"1974"},{"key":"bibr10-000348948309200213","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401130110"},{"key":"bibr11-000348948309200213","first-page":"293","volume":"56","author":"Sax\u00e9n L","year":"1978","journal-title":"Med Biol"},{"key":"bibr12-000348948309200213","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3002(61)90266-9"},{"key":"bibr13-000348948309200213","first-page":"380","volume":"56","author":"Tarin D","year":"1978","journal-title":"Med Biol"},{"key":"bibr14-000348948309200213","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100063234"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348948309200213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348948309200213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:30:29Z","timestamp":1777375829000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348948309200213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,3]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1983,3]]}},"alternative-id":["10.1177\/000348948309200213"],"URL":"https:\/\/doi.org\/10.1177\/000348948309200213","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,3]]}}}