{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:27:34Z","timestamp":1777426054445,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1983,5,1]],"date-time":"1983-05-01T00:00:00Z","timestamp":420595200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[1983,5]]},"abstract":"<jats:p>\n                    As it is not known whether individuals with \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    -antitrypsin deficiency show increased sequelae following otitis media, 52 patients with \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    -antitrypsin deficiency were studied with respect to history of middle ear disease, presence of irreversible pathologic changes of the tympanic membranes, and hearing ability. The middle ear status was determined on otomicroscopy, tympanometry, and pure-tone audiometry. The frequency of individuals with a history of otitis media was 50%. The frequency of individuals with pathologic tympanic membrane changes was no different from that shown in the results obtained in a Swedish normal population study. Minor conductive hearing losses were found in three patients of which only one was related to a history of middle ear disease. However, the history of acute severe complications from otitis media revealed a higher frequency in those individuals with \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    -antitrypsin deficiency as compared to normals.\n                  <\/jats:p>","DOI":"10.1177\/000348948309200317","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:35:41Z","timestamp":1412346941000},"page":"300-304","source":"Crossref","is-referenced-by-count":2,"title":["Middle Ear Disorders in Patients with Alpha\n                    <sub>1<\/sub>\n                    -Antitrypsin Deficiency"],"prefix":"10.1177","volume":"92","author":[{"given":"Britt","family":"Carlsson","sequence":"first","affiliation":[{"name":"Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1983,5,1]]},"reference":[{"key":"bibr1-000348948309200317","doi-asserted-by":"publisher","DOI":"10.1177\/000348948209100117"},{"key":"bibr2-000348948309200317","doi-asserted-by":"publisher","DOI":"10.3109\/00016488309130952"},{"key":"bibr3-000348948309200317","doi-asserted-by":"publisher","DOI":"10.1177\/000348948109000110"},{"key":"bibr4-000348948309200317","first-page":"869","volume":"57","author":"Kastenbauer E","year":"1978","journal-title":"Laryngol Rhinol Otol (Stuttg)"},{"key":"bibr5-000348948309200317","first-page":"96","volume":"7","author":"Fagerhol M","year":"1970","journal-title":"Prog Med Genet"},{"key":"bibr6-000348948309200317","doi-asserted-by":"publisher","DOI":"10.3109\/00365516909078092"},{"key":"bibr7-000348948309200317","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197811092991905"},{"key":"bibr8-000348948309200317","doi-asserted-by":"publisher","DOI":"10.3109\/00365516709090627"},{"key":"bibr9-000348948309200317","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.0954-6820.1965.tb01796.x","volume":"177","author":"Eriksson S","year":"1965","journal-title":"Acta Med Scand"},{"key":"bibr10-000348948309200317","first-page":"934","volume":"73","author":"Sharp HL","year":"1969","journal-title":"J Lab Clin Med"},{"key":"bibr11-000348948309200317","first-page":"1216","volume":"1","author":"Cox DW","year":"1976","journal-title":"Lancet"},{"key":"bibr12-000348948309200317","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)90041-1"},{"key":"bibr13-000348948309200317","doi-asserted-by":"publisher","DOI":"10.3109\/00365517209102748"},{"key":"bibr14-000348948309200317","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/28.1.219"},{"key":"bibr15-000348948309200317","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1974.00780030219013"},{"key":"bibr16-000348948309200317","doi-asserted-by":"publisher","DOI":"10.3109\/00206097409071671"},{"key":"bibr17-000348948309200317","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6092.922"},{"key":"bibr18-000348948309200317","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3109\/00016346709158192","volume":"46","author":"Ganrot PO","year":"1967","journal-title":"Acta Obstet Gynecol Scand"},{"key":"bibr19-000348948309200317","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3109\/00365515509134092","volume":"7","author":"Jacobsson K","year":"1955","journal-title":"Scand J Clin Lab Invest"},{"key":"bibr20-000348948309200317","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197301112880201"},{"key":"bibr21-000348948309200317","doi-asserted-by":"crossref","unstructured":"Ingvarsson L, Lundgren K, Olofsson B, Wall S. A prospective study of acute otitis media in children. 2. Incidence in an urban population. Acta Otolaryngol (Stockh) 1982; Suppl 388: 29\u201352.","DOI":"10.3109\/00016488209123527"},{"key":"bibr22-000348948309200317","first-page":"676","volume":"129","author":"Howie V","year":"1975","journal-title":"Am J Dis Child"},{"key":"bibr23-000348948309200317","doi-asserted-by":"publisher","DOI":"10.1177\/00034894800890S304"},{"key":"bibr24-000348948309200317","first-page":"510","volume":"2","author":"Medical Research Council.","year":"1957","journal-title":"Lancet"},{"key":"bibr25-000348948309200317","doi-asserted-by":"crossref","unstructured":"Paavolainen M. Incidence, etiology and prognosis of acute purulent otitis media in Helsinki residents of various ages. Acta Otolaryngol (Stockh) 1967; Suppl 224: 360\u201371.","DOI":"10.3109\/00016486709123605"},{"key":"bibr26-000348948309200317","unstructured":"Rudin R, Sv\u00e4rdsudd K, Tibblin G, Hall\u00e9n O. Middle ear disease in samples from the general population. Acta Otolaryngol (Stockh) 1983 (in press)."},{"key":"bibr27-000348948309200317","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1978.tb08452.x"},{"key":"bibr28-000348948309200317","doi-asserted-by":"publisher","DOI":"10.1177\/00034894800890S306"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348948309200317","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348948309200317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:30:35Z","timestamp":1777375835000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348948309200317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,5]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1983,5]]}},"alternative-id":["10.1177\/000348948309200317"],"URL":"https:\/\/doi.org\/10.1177\/000348948309200317","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,5]]}}}