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Sixteen percent of patients who suffered local or regional failure were salvaged by further surgery. Distant metastases developed in approximately 18% of patients and second malignancies developed in 20%. It appears that the combination of preoperative irradiation plus surgery provides substantial local control rates and survival for patients with base of tongue cancer in both early and moderately advanced stages.<\/jats:p>","DOI":"10.1177\/000348948309200516","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:35:41Z","timestamp":1412346941000},"page":"485-490","source":"Crossref","is-referenced-by-count":40,"title":["Preoperative Irradiation and Surgery for Carcinoma of the Base of the Tongue"],"prefix":"10.1177","volume":"92","author":[{"given":"Stanley E.","family":"Thawley","sequence":"first","affiliation":[{"name":"St Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph R.","family":"Simpson","sequence":"additional","affiliation":[{"name":"St Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A.","family":"Perez","sequence":"additional","affiliation":[{"name":"St Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E.","family":"Marks","sequence":"additional","affiliation":[{"name":"St Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph H.","family":"Ogura","sequence":"additional","affiliation":[{"name":"St Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1983,9,1]]},"reference":[{"key":"bibr1-000348948309200516","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(67)90004-9"},{"key":"bibr2-000348948309200516","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197508000-00009"},{"key":"bibr3-000348948309200516","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197210000-00010"},{"key":"bibr4-000348948309200516","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)40379-8"},{"key":"bibr5-000348948309200516","first-page":"20","volume":"93","author":"Dalley VM","year":"1965","journal-title":"AJR"},{"key":"bibr6-000348948309200516","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810115)47:2<333::AID-CNCR2820470221>3.0.CO;2-9"},{"key":"bibr7-000348948309200516","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197606)37:6<2591::AID-CNCR2820370605>3.0.CO;2-7"},{"key":"bibr8-000348948309200516","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(79)90947-7"},{"key":"bibr9-000348948309200516","first-page":"26","volume":"1054","author":"Scanlon PW","year":"1969","journal-title":"Radiology"},{"key":"bibr10-000348948309200516","volume-title":"Textbook of radiotherapy","author":"Fletcher G","year":"1980","edition":"3"},{"key":"bibr11-000348948309200516","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.111.1.73"},{"key":"bibr12-000348948309200516","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197210000-00007"},{"key":"bibr13-000348948309200516","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1288\/00005537-197108000-00005","volume":"81","author":"Sessions DG","year":"1971","journal-title":"Laryngoscope"},{"key":"bibr14-000348948309200516","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1978.00790060031008"},{"key":"bibr15-000348948309200516","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(78)90269-6"},{"key":"bibr16-000348948309200516","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/1097-0142(196211\/12)15:6<1085::AID-CNCR2820150602>3.0.CO;2-R","volume":"15","author":"Frazell E","year":"1962","journal-title":"Cancer"},{"key":"bibr17-000348948309200516","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(76)90314-7"},{"key":"bibr18-000348948309200516","unstructured":"American Joint Committee for Cancer Staging and End Results Reporting. 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