{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:15:50Z","timestamp":1777425350413,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1985,3,1]],"date-time":"1985-03-01T00:00:00Z","timestamp":478483200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[1985,3]]},"abstract":"<jats:p>\n                    An increased number (density) or sensitivity (affinity) of histamine H\n                    <jats:sub>1<\/jats:sub>\n                    receptors could cause an increase of allergic symptoms. Using the specific H\n                    <jats:sub>1<\/jats:sub>\n                    receptor blocker\n                    <jats:sup>3<\/jats:sup>\n                    H-mepyramine, we have demonstrated for the first time an H\n                    <jats:sub>1<\/jats:sub>\n                    receptor number (Bmax) and a binding affinity (Kd) in guinea pig and human nasal mucosa. H\n                    <jats:sub>1<\/jats:sub>\n                    antihistamines inhibited\n                    <jats:sup>3<\/jats:sup>\n                    H-mepyramine binding in nasal mucosa at low concentrations, while H\n                    <jats:sub>2<\/jats:sub>\n                    antihistamines inhibited at extremely high concentrations, indicating that\n                    <jats:sup>3<\/jats:sup>\n                    H-mepyramine binding sites represent H\n                    <jats:sub>1<\/jats:sub>\n                    receptors in nasal mucosa. Bmax and Kd values were not significantly different among the nonallergic sinusitis, vasomotor rhinitis, or the nasal allergy group, suggesting that H\n                    <jats:sub>1<\/jats:sub>\n                    receptors do not change quantitatively and qualitatively in allergic nasal mucosa. There was no significant correlation between H\n                    <jats:sub>1<\/jats:sub>\n                    receptor number and clinical data (IgE, peripheral eosinophils, RAST). These data suggest that H\n                    <jats:sub>1<\/jats:sub>\n                    receptor number and affinity are not main etiological and pathophysiological factors in nasal allergy.\n                  <\/jats:p>","DOI":"10.1177\/000348948509400218","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T09:10:30Z","timestamp":1483693830000},"page":"186-190","source":"Crossref","is-referenced-by-count":20,"title":["Histamine H1 Receptors and Affinity Analyses in Human Nasal Mucosa in Cases of Nasal Allergy"],"prefix":"10.1177","volume":"94","author":[{"given":"Tsukasa","family":"Ishibe","sequence":"first","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Kubo","sequence":"additional","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Kumazawa","sequence":"additional","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadami","family":"Kamazawa","sequence":"additional","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1985,3,1]]},"reference":[{"key":"bibr1-000348948509400218","first-page":"609","volume-title":"Goodman and Gilman's the pharmacological basis of therapeutics","author":"Douglas WW","year":"1980","edition":"6"},{"key":"bibr2-000348948509400218","doi-asserted-by":"publisher","DOI":"10.1007\/BF00457450"},{"key":"bibr3-000348948509400218","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(81)90065-8"},{"key":"bibr4-000348948509400218","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(82)90044-6"},{"key":"bibr5-000348948509400218","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(82)90036-7"},{"key":"bibr6-000348948509400218","doi-asserted-by":"publisher","DOI":"10.1007\/BF00454309"},{"key":"bibr7-000348948509400218","doi-asserted-by":"publisher","DOI":"10.1038\/270361a0"},{"key":"bibr8-000348948509400218","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.12.6290"},{"key":"bibr9-000348948509400218","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(79)90495-8"},{"key":"bibr10-000348948509400218","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"bibr11-000348948509400218","doi-asserted-by":"publisher","DOI":"10.1002\/lary.5540801207"},{"key":"bibr12-000348948509400218","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(82)90448-4"},{"key":"bibr13-000348948509400218","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100060229"},{"key":"bibr14-000348948509400218","first-page":"27","volume":"19","author":"Parrot JL","year":"1961","journal-title":"Med Hyg"},{"key":"bibr15-000348948509400218","unstructured":"Pare PD, Hogg JC. Pathophysiological basis for inhaled steroid treatment for asthma and rhinitis. London: Bailliere Tindall, 1980: 12."},{"key":"bibr16-000348948509400218","doi-asserted-by":"publisher","DOI":"10.3109\/00016487609120899"},{"key":"bibr17-000348948509400218","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(83)90071-4"},{"key":"bibr18-000348948509400218","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109702"},{"key":"bibr19-000348948509400218","doi-asserted-by":"publisher","DOI":"10.1016\/0021-8707(53)90058-6"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348948509400218","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348948509400218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:29:08Z","timestamp":1777375748000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348948509400218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,3]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1985,3]]}},"alternative-id":["10.1177\/000348948509400218"],"URL":"https:\/\/doi.org\/10.1177\/000348948509400218","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,3]]}}}