{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:21:34Z","timestamp":1777425694340,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1986,3,1]],"date-time":"1986-03-01T00:00:00Z","timestamp":510019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[1986,3]]},"abstract":"<jats:p>The LP\/J inbred mouse is the first known animal to spontaneously develop otosclerosis-like bone lesions in the middle and inner ear. These abnormal bone foci resemble human otosclerotic lesions, are inherited, and produce a progressive hearing loss. On the basis of histological evaluation alone, it was unclear whether these otosclerosis-like lesions in LP\/J mice develop suddenly or gradually as in human otosclerosis. To study the dynamics of lesion formation, four different colored fluorochrome bone labels were given in sequence to postpubertal LP\/J mice and CBA\/J mice as normal controls. All of the otosclerosis-like lesions incorporated at least one fluorochrome, and half were labeled with two or more markers indicating continuous lesion growth over many weeks. It appears that otosclerosis-like lesions in LP\/J mice develop during early adulthood and progress gradually as in human otosclerosis.<\/jats:p>","DOI":"10.1177\/000348948609500212","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:35:41Z","timestamp":1412346941000},"page":"169-172","source":"Crossref","is-referenced-by-count":10,"title":["Dynamics of Otosclerosis-Like Lesions in LP\/J Mice"],"prefix":"10.1177","volume":"95","author":[{"given":"Henry B.","family":"Cramer","sequence":"first","affiliation":[{"name":"Davis, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Chole","sequence":"additional","affiliation":[{"name":"Davis, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,3,1]]},"reference":[{"key":"bibr1-000348948609500212","first-page":"11","volume":"91","author":"Ward PH","year":"1982","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"bibr2-000348948609500212","volume-title":"Pathology of the ear","author":"Schuknecht HF","year":"1974"},{"key":"bibr3-000348948609500212","doi-asserted-by":"publisher","DOI":"10.3109\/00016483009120116"},{"key":"bibr4-000348948609500212","first-page":"6","volume":"70","author":"Krainz W","year":"1936","journal-title":"Monatsschr Ohrenheilkd Laryngo-Rhinol"},{"key":"bibr5-000348948609500212","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1960.03770020096014"},{"key":"bibr6-000348948609500212","doi-asserted-by":"publisher","DOI":"10.3109\/00016486909124363"},{"key":"bibr7-000348948609500212","doi-asserted-by":"publisher","DOI":"10.1126\/science.7112122"},{"key":"bibr8-000348948609500212","doi-asserted-by":"publisher","DOI":"10.1126\/science.6879187"},{"key":"bibr9-000348948609500212","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197052020-00008"},{"key":"bibr10-000348948609500212","first-page":"157","volume":"17","author":"Modis L","year":"1969","journal-title":"Acta Morphol Acad Sci Hung"},{"key":"bibr11-000348948609500212","doi-asserted-by":"publisher","DOI":"10.1038\/1881038a0"},{"key":"bibr12-000348948609500212","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(69)90033-1"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348948609500212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348948609500212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:29:52Z","timestamp":1777375792000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348948609500212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,3]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1986,3]]}},"alternative-id":["10.1177\/000348948609500212"],"URL":"https:\/\/doi.org\/10.1177\/000348948609500212","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,3]]}}}