{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:21:01Z","timestamp":1777425661002,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1990,5,1]],"date-time":"1990-05-01T00:00:00Z","timestamp":641520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:p>The cause of otosclerosis is still unclear. Between 1981 and 1988 we obtained 186 biopsy specimens of otosclerotic bone during the course of stapedectomies. Serial sections of the specimens were examined histologically (H &amp; E) and immunohistologically (peroxidase-antiperoxidase technique) for immunoglobulin G, immunoglobulin M, and C1q and C3 complements. Active otosclerotic foci were found in 61 cases, 43 of which had IgG deposits. IgM antibodies were absent. In specimens with inactive otosclerosis, IgG and IgM were not evident. C1q and C3 complements were demonstrated together with IgG, but sometimes also in the mucosa independent of the phase of the otosclerosis. Our findings suggest that an immunologic process may be important in the pathogenesis of otosclerosis.<\/jats:p>","DOI":"10.1177\/000348949009900506","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:38:05Z","timestamp":1412347085000},"page":"349-352","source":"Crossref","is-referenced-by-count":18,"title":["Immunohistologic Findings in Otosclerosis"],"prefix":"10.1177","volume":"99","author":[{"given":"Martin","family":"Schrader","sequence":"first","affiliation":[{"name":"Essen, Federal Republic of Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joerg","family":"Poppendieck","sequence":"additional","affiliation":[{"name":"T\u00fcbingen, Federal Republic of Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benno","family":"Weber","sequence":"additional","affiliation":[{"name":"T\u00fcbingen, Federal Republic of Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1990,5,1]]},"reference":[{"key":"bibr1-000348949009900506","unstructured":"Larsson A. Otosclerosis. A genetic and clinical study. Acta Otolaryngol [Suppl] (Stockh) 1960(suppl 154)."},{"key":"bibr2-000348949009900506","first-page":"211","volume":"5","author":"Causse JR","year":"1984","journal-title":"Am J Otol"},{"key":"bibr3-000348949009900506","doi-asserted-by":"publisher","DOI":"10.1126\/science.7112122"},{"key":"bibr4-000348949009900506","first-page":"43","volume":"6","author":"Petrovic AG","year":"1985","journal-title":"Am J Otol"},{"key":"bibr5-000348949009900506","first-page":"65","volume":"243","author":"Schrader M","year":"1986","journal-title":"Arch Otorhinolaryngol"},{"key":"bibr6-000348949009900506","doi-asserted-by":"publisher","DOI":"10.1177\/18.5.315"},{"key":"bibr7-000348949009900506","first-page":"15","volume-title":"Otosclerosis \u2014 Henry Ford International Symposium","author":"Altmann H.","year":"1962"},{"key":"bibr8-000348949009900506","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1963.00750020481009"},{"key":"bibr9-000348949009900506","first-page":"163","volume":"12","author":"Brondbo K","year":"1983","journal-title":"J Otolaryngol"},{"key":"bibr10-000348949009900506","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1969.00770020343022"},{"key":"bibr11-000348949009900506","first-page":"245","volume-title":"Pathology of the ear","author":"Friedmann I.","year":"1974"},{"key":"bibr12-000348949009900506","first-page":"351","volume-title":"Pathology of the ear","author":"Schuknecht H.","year":"1974"},{"key":"bibr13-000348949009900506","doi-asserted-by":"publisher","DOI":"10.1007\/BF00316931"},{"key":"bibr14-000348949009900506","first-page":"665","volume":"39","author":"Wullstein HL","year":"1960","journal-title":"Z Laryngol Rhinol Otol Ihre Grenzgeb"},{"key":"bibr15-000348949009900506","doi-asserted-by":"publisher","DOI":"10.3109\/00016487209128418"},{"key":"bibr16-000348949009900506","doi-asserted-by":"publisher","DOI":"10.3109\/00016486909121560"},{"key":"bibr17-000348949009900506","doi-asserted-by":"publisher","DOI":"10.1177\/000348948409300107"},{"key":"bibr18-000348949009900506","doi-asserted-by":"publisher","DOI":"10.1177\/000348948309200201"},{"key":"bibr19-000348949009900506","doi-asserted-by":"publisher","DOI":"10.1177\/000348948609500214"},{"key":"bibr20-000348949009900506","first-page":"201","volume-title":"Immunobiology, histophysiology, and tumor immunology in otolaryngology","author":"Bretlau P","year":"1987"},{"key":"bibr21-000348949009900506","doi-asserted-by":"publisher","DOI":"10.1177\/000348948609500212"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348949009900506","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348949009900506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:29:49Z","timestamp":1777375789000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348949009900506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,5]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1990,5]]}},"alternative-id":["10.1177\/000348949009900506"],"URL":"https:\/\/doi.org\/10.1177\/000348949009900506","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,5]]}}}