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Significant differences in average IgE levels between the 42 patients with Meniere's disease and 18 normal control subjects were not determined; however, five (11.9 %) of the 42 patients were found to have obviously raised IgE levels. Elevated CIC levels were found in 19 (32.2 %) of the 59 patients with Meniere's disease and in one (2.3 %) of the 43 control subjects. This difference was statistically significant. The possible mechanisms of immune-mediated endolymphatic hydrops are discussed.<\/jats:p>","DOI":"10.1177\/000348949009900707","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:38:05Z","timestamp":1412347085000},"page":"535-538","source":"Crossref","is-referenced-by-count":22,"title":["Immunoglobulin E and Circulating Immune Complexes in Endolymphatic Hydrops"],"prefix":"10.1177","volume":"99","author":[{"given":"Lee","family":"Hsu","sequence":"first","affiliation":[{"name":"Beijing, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Nong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Beijing, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Shi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1990,7,1]]},"reference":[{"key":"bibr1-000348949009900707","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)32775-4"},{"key":"bibr2-000348949009900707","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)32786-9"},{"key":"bibr3-000348949009900707","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1923.02650260021006"},{"key":"bibr4-000348949009900707","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197209000-00013"},{"key":"bibr5-000348949009900707","first-page":"22","volume":"77","author":"Powers WH","year":"1973","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"bibr6-000348949009900707","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197710000-00006"},{"key":"bibr7-000348949009900707","doi-asserted-by":"publisher","DOI":"10.1177\/000348947908800501"},{"key":"bibr8-000348949009900707","doi-asserted-by":"publisher","DOI":"10.1177\/00034894840930S503"},{"key":"bibr9-000348949009900707","first-page":"119","volume-title":"Immunobiology, autoimmunity, transplantation in otorhinolaryngology","author":"Hughes GB","year":"1985"},{"key":"bibr10-000348949009900707","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1986.03780050060010"},{"key":"bibr11-000348949009900707","doi-asserted-by":"publisher","DOI":"10.1177\/019459988509300501"},{"key":"bibr12-000348949009900707","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(77)90051-5"},{"key":"bibr13-000348949009900707","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(65)90004-2"},{"key":"bibr14-000348949009900707","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197209000-00011"},{"key":"bibr15-000348949009900707","doi-asserted-by":"publisher","DOI":"10.1007\/BF00453676"},{"key":"bibr16-000348949009900707","first-page":"65","volume":"38","author":"Miyamura K","year":"1986","journal-title":"Kumamoto Med J"},{"key":"bibr17-000348949009900707","doi-asserted-by":"publisher","DOI":"10.5631\/jibirin.73.527"},{"key":"bibr18-000348949009900707","doi-asserted-by":"publisher","DOI":"10.3109\/00016488409132920"},{"key":"bibr19-000348949009900707","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1983.93.4.410"},{"key":"bibr20-000348949009900707","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197309000-00007"},{"key":"bibr21-000348949009900707","doi-asserted-by":"publisher","DOI":"10.1177\/00034894840930S420"},{"key":"bibr22-000348949009900707","doi-asserted-by":"publisher","DOI":"10.3109\/00016488009127140"},{"key":"bibr23-000348949009900707","doi-asserted-by":"publisher","DOI":"10.1177\/000348948409300211"},{"key":"bibr24-000348949009900707","first-page":"330","volume":"8","author":"Sawada I","year":"1987","journal-title":"Am J Otol"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348949009900707","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348949009900707","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:29:59Z","timestamp":1777375799000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348949009900707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,7]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1990,7]]}},"alternative-id":["10.1177\/000348949009900707"],"URL":"https:\/\/doi.org\/10.1177\/000348949009900707","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,7]]}}}