{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:23:22Z","timestamp":1777425802466,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[1990,8,1]],"date-time":"1990-08-01T00:00:00Z","timestamp":649468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[1990,8]]},"abstract":"<jats:p>Delayed immunologic maturation \u2014 Among other things based on a selective lack of antibodies against some acute purulent otitis media (AOM)\u2013associated pneumococcal types \u2014 has been proposed in children with recurrent AOM (rAOM). To further elucidate the immunologic response in these children, we compared the antibody responses to diphtheria, tetanus, and rubella vaccinations in 13 children with rAOM and 29 children without AOM. The children took part in a prospective study from birth to the age of 3 years. The antibody response to the rubella vaccine was significantly lower in the children with rAOM. The responses to tetanus and to diphtheria did not differ between children with and without rAOM. Thus, the results indicate that in addition to the known lack of antibodies against pneumococcal polysaccharide antigens, a lower antibody response against at least one protein antigen may exist in otitis-prone children.<\/jats:p>","DOI":"10.1177\/000348949009900808","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:38:05Z","timestamp":1412347085000},"page":"628-632","source":"Crossref","is-referenced-by-count":13,"title":["Responses to Rubella, Tetanus, and Diphtheria Vaccines in Otitis-Prone and Non-Otitis-Prone Children"],"prefix":"10.1177","volume":"99","author":[{"given":"Karin","family":"Prellner","sequence":"first","affiliation":[{"name":"Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"Harsten","sequence":"additional","affiliation":[{"name":"Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brith","family":"Christenson","sequence":"additional","affiliation":[{"name":"Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengt","family":"L\u00f6fgren","sequence":"additional","affiliation":[{"name":"Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper","family":"Heldrup","sequence":"additional","affiliation":[{"name":"Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1990,8,1]]},"reference":[{"key":"bibr1-000348949009900808","doi-asserted-by":"publisher","DOI":"10.3109\/inf.1970.2.issue-3.06"},{"key":"bibr2-000348949009900808","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.9.6.1028-1032.1974"},{"key":"bibr3-000348949009900808","first-page":"10","volume":"85","author":"Johnson U","year":"1977","journal-title":"Acta Pathol Microbiol Scand [C]"},{"key":"bibr4-000348949009900808","doi-asserted-by":"publisher","DOI":"10.3109\/00016488209128914"},{"key":"bibr5-000348949009900808","first-page":"233","volume":"56","author":"Freijd A","year":"1984","journal-title":"Clin Exp Immunol"},{"key":"bibr6-000348949009900808","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(84)80052-X"},{"key":"bibr7-000348949009900808","doi-asserted-by":"publisher","DOI":"10.1159\/000233604"},{"key":"bibr8-000348949009900808","first-page":"155","volume-title":"Recent advances in otitis media with effusion","author":"Shurin PA","year":"1984"},{"key":"bibr9-000348949009900808","doi-asserted-by":"publisher","DOI":"10.3109\/00016488909127487"},{"key":"bibr10-000348949009900808","doi-asserted-by":"publisher","DOI":"10.1016\/0092-1157(74)90015-8"},{"key":"bibr11-000348949009900808","doi-asserted-by":"publisher","DOI":"10.1016\/0092-1157(74)90016-X"},{"key":"bibr12-000348949009900808","volume":"10","author":"Jensen C","year":"1933","journal-title":"Acta Pathol Microbiol Scand"},{"key":"bibr13-000348949009900808","doi-asserted-by":"publisher","DOI":"10.3109\/00365548609032331"},{"key":"bibr14-000348949009900808","doi-asserted-by":"publisher","DOI":"10.1016\/0092-1157(86)90008-9"},{"key":"bibr15-000348949009900808","doi-asserted-by":"publisher","DOI":"10.3109\/00365548709021675"},{"key":"bibr16-000348949009900808","first-page":"347","volume":"102","author":"Ipsen J","year":"1942","journal-title":"Z Immunit\u00e4tsforsch"},{"key":"bibr17-000348949009900808","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.1.6.491-494.1975"},{"key":"bibr18-000348949009900808","doi-asserted-by":"publisher","DOI":"10.3109\/00016487509121343"},{"key":"bibr19-000348949009900808","doi-asserted-by":"publisher","DOI":"10.1177\/00034894800890S331"},{"key":"bibr20-000348949009900808","first-page":"143","volume-title":"Recent advances in otitis media","author":"Pelton SI","year":"1988"},{"key":"bibr21-000348949009900808","first-page":"146","volume-title":"Recent advances in otitis media","author":"Heldrup J","year":"1988"},{"key":"bibr22-000348949009900808","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/7.Supplement_1.S140"},{"key":"bibr23-000348949009900808","unstructured":"Cruickshank R, Duguid JP, Marmion BP, Swain RHA. 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