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Standardized TM perforations, occupying the whole upper rear quadrant, were performed, and a 2% hydrocortisone suspension (CORT) was applied once daily for 10 consecutive days. Application of CORT caused a delayed healing pattern, and even at 1 month only 2 of 12 perforations had healed. The keratinizing squamous epithelial cells of the TM appeared hypertrophic, whereas hyperplasia, characterizing a nontreated healing TM perforation, was less prominent. The connective tissue layer of the CORT-treated TM was invaded by abundant inflammatory cells, mainly polymorphonuclear leukocytes. Also, when applied to an intact TM, CORT caused hypertrophy of the epidermal cells and an inflammatory reaction within the TM.<\/jats:p>","DOI":"10.1177\/000348949009900812","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:38:05Z","timestamp":1412347085000},"page":"647-653","source":"Crossref","is-referenced-by-count":26,"title":["Hydrocortisone Delay of Tissue Repair of Experimental Tympanic Membrane Perforations"],"prefix":"10.1177","volume":"99","author":[{"given":"Odd","family":"Spandow","sequence":"first","affiliation":[{"name":"Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sten","family":"Hellstr\u00f6m","sequence":"additional","affiliation":[{"name":"Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sten-Hermann","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1990,8,1]]},"reference":[{"key":"bibr1-000348949009900812","first-page":"1023","volume":"15","year":"1971","journal-title":"Swedish Adverse Drug Reactions Advisory Committee (SADRAC)"},{"key":"bibr2-000348949009900812","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197210000-00005"},{"key":"bibr3-000348949009900812","first-page":"353","volume":"7","author":"Sch\u00f6pf E","year":"1975","journal-title":"Ann Clin Res"},{"key":"bibr4-000348949009900812","doi-asserted-by":"publisher","DOI":"10.1159\/000276040"},{"key":"bibr5-000348949009900812","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100063490"},{"key":"bibr6-000348949009900812","doi-asserted-by":"publisher","DOI":"10.1177\/000348947007900617"},{"key":"bibr7-000348949009900812","first-page":"1302","volume":"75","author":"Clawson JP","year":"1971","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"bibr8-000348949009900812","unstructured":"Reijnen CJH, Kuijpers W. 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