{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:38:37Z","timestamp":1792726717203,"version":"4.5.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1991,5,1]],"date-time":"1991-05-01T00:00:00Z","timestamp":673056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[1991,5]]},"abstract":"<jats:p>Aminoglycosides were applied to the endolymphatic sac of guinea pigs, and the inner ears were studied by light microscopy, In group 1 gentamicin sulfate application on the lateral surface of the endolymphatic sac produced sensory cell atrophy limited to the macula sacculi. In group 2 gentamicin injection into the sac by extradural and intradural approaches often showed lesions in the maculae sacculi and utriculi, cristae of the three ampullae, and organ of Corti in the basal turn. In group 3 passive instillation of streptomycin sulfate pellets into the sac from a lateral opening resulted in a similar pattern of degeneration but with less severity in comparison to the injection method. Mild to severe endolymphatic hydrops was sometimes observed. The study shows diffusion of drugs taking place against the longitudinal flow of endolymph. This procedure may be applicable for the treatment of Meniere's disease.<\/jats:p>","DOI":"10.1177\/000348949110000502","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:38:05Z","timestamp":1412347085000},"page":"355-360","source":"Crossref","is-referenced-by-count":13,"title":["Effect of Ototoxic Drug Administration to the Endolymphatic SAC"],"prefix":"10.1177","volume":"100","author":[{"given":"Kwang Sun","family":"Lee","sequence":"first","affiliation":[{"name":"Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Kimura","sequence":"additional","affiliation":[{"name":"Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1991,5,1]]},"reference":[{"key":"bibr1-000348949110000502","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(85)80013-2"},{"key":"bibr2-000348949110000502","unstructured":"Berg K. The toxic effect of streptomycin on the vestibular and cochlear apparatus. An experimental study on cats. Acta Otolaryngol [Suppl] (Stockh) 1951(suppl 97)."},{"key":"bibr3-000348949110000502","first-page":"293","volume":"52","author":"Fowler EP","year":"1948","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"bibr4-000348949110000502","unstructured":"Schuknecht HF. Ablation therapy in the management of M\u00e9ni\u00e8re's disease. Acta Otolaryngol [Suppl] (Stockh) 1957(suppl 132)."},{"key":"bibr5-000348949110000502","doi-asserted-by":"publisher","DOI":"10.1177\/019459988409200413"},{"key":"bibr6-000348949110000502","doi-asserted-by":"publisher","DOI":"10.1007\/BF00455886"},{"key":"bibr7-000348949110000502","first-page":"208","volume-title":"M\u00e9ni\u00e8re's disease. Pathogenesis, diagnosis and treatment","author":"Lange G","year":"1981"},{"key":"bibr8-000348949110000502","first-page":"89","volume":"75","author":"Shea JJ","year":"1987","journal-title":"Trans Am Otol Soc"},{"key":"bibr9-000348949110000502","doi-asserted-by":"publisher","DOI":"10.1177\/000348948809700602"},{"key":"bibr10-000348949110000502","first-page":"84","volume":"75","author":"Norris CH","year":"1987","journal-title":"Trans Am Otol Soc"},{"key":"bibr11-000348949110000502","doi-asserted-by":"publisher","DOI":"10.1177\/000348946707600311"},{"key":"bibr12-000348949110000502","first-page":"26","volume-title":"Gentamicin","author":"Lundquist P-G","year":"1967"},{"key":"bibr13-000348949110000502","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1962.00740040304003"},{"key":"bibr14-000348949110000502","unstructured":"Kohonen A. Effect of some ototoxic drugs upon the pattern and innervation of cochlear sensory cells in the guinea pig. Acta Otolaryngol [Suppl] (Stockh) 1965(suppl 208)."},{"key":"bibr15-000348949110000502","first-page":"174","volume":"101","author":"Norris CH","year":"1989","journal-title":"Otolaryngol Head Neck Surg"},{"key":"bibr16-000348949110000502","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1008612"},{"key":"bibr17-000348949110000502","unstructured":"Pr\u00f6schel U, Sellick PM, Johnstone BM. Measurements of endolymph flow by iontophoresis of ototoxic substances into scala media. Proceedings of the 21st Workshop on Inner Ear Biology. Taormina, Italy: 1984: 88."},{"key":"bibr18-000348949110000502","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(87)90047-5"},{"key":"bibr19-000348949110000502","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0378-5955(88)90159-1","volume":"33","author":"Yates GK","year":"1988","journal-title":"Hear Res"},{"key":"bibr20-000348949110000502","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(86)90011-0"},{"key":"bibr21-000348949110000502","doi-asserted-by":"publisher","DOI":"10.3109\/00016488109138539"},{"key":"bibr22-000348949110000502","first-page":"110","volume-title":"M\u00e9ni\u00e8re's disease. Pathogenesis, diagnosis and treatment","author":"Arnold W","year":"1981"},{"key":"bibr23-000348949110000502","first-page":"421","volume-title":"Proceedings of the Second International Symposium on M\u00e9ni\u00e8re's Disease","author":"Kimura RS","year":"1989"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348949110000502","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348949110000502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:15:18Z","timestamp":1777374918000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348949110000502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,5]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1991,5]]}},"alternative-id":["10.1177\/000348949110000502"],"URL":"https:\/\/doi.org\/10.1177\/000348949110000502","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,5]]}}}