{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:46:56Z","timestamp":1777420016138,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1993,1,1]],"date-time":"1993-01-01T00:00:00Z","timestamp":725846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[1993,1]]},"abstract":"\n Movements of potassium (K\n +<\/jats:sup>\n ) were monitored during perfusion of either the scala tympani (ST) or the scala vestibuli (SV) of the guinea pig cochlea with a solution containing 15 mmol\/LK\n +<\/jats:sup>\n . A highly asymmetric clearance of K\n +<\/jats:sup>\n was observed, with K\n +<\/jats:sup>\n rapidly being taken up from the ST and allowed to accumulate in the SV. Under some conditions the SV K\n +<\/jats:sup>\n concentration could exceed that in the perfused ST. These observations are believed to result from the distortion of passive K\n +<\/jats:sup>\n diffusion by the high circulating current of K\n +<\/jats:sup>\n that is part of the transduction process. Calculations are presented to demonstrate that circulating fluxes are of sufficient magnitude to generate the results observed. The high rate of circulating K\n +<\/jats:sup>\n current is probably also responsible for the difference in physiologic K\n +<\/jats:sup>\n concentration between the ST and SV, in which the ST perilymph K\n +<\/jats:sup>\n concentration is typically found to be half that of the SV. A clearance of K\n +<\/jats:sup>\n from the ST and its eventual accumulation in the SV could play a role in how the ear responds to abnormal ion concentrations, such as may occur in Meniere's disease. It is proposed that an accumulation of K\n +<\/jats:sup>\n in the SV would result in vestibular dysfunction that might contribute to the vestibular symptoms of the disease.\n <\/jats:p>","DOI":"10.1177\/000348949310200112","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:38:05Z","timestamp":1412347085000},"page":"64-70","source":"Crossref","is-referenced-by-count":19,"title":["Accumulation of Potassium in Scala Vestibuli Perilymph of the Mammalian Cochlea"],"prefix":"10.1177","volume":"102","author":[{"given":"Alec N.","family":"Salt","sequence":"first","affiliation":[{"name":"St Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Ohyama","sequence":"additional","affiliation":[{"name":"Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1993,1,1]]},"reference":[{"key":"bibr1-000348949310200112","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-195403000-00001"},{"key":"bibr2-000348949310200112","doi-asserted-by":"publisher","DOI":"10.1038\/281675a0"},{"key":"bibr3-000348949310200112","doi-asserted-by":"publisher","DOI":"10.1038\/301334a0"},{"key":"bibr4-000348949310200112","first-page":"109","volume-title":"The cochlea","author":"Salt AN","year":"1986"},{"key":"bibr5-000348949310200112","doi-asserted-by":"publisher","DOI":"10.3109\/00016487909137160"},{"key":"bibr6-000348949310200112","doi-asserted-by":"publisher","DOI":"10.3109\/00016489109138428"},{"key":"bibr7-000348949310200112","doi-asserted-by":"publisher","DOI":"10.1007\/BF00464343"},{"key":"bibr8-000348949310200112","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(91)90150-8"},{"key":"bibr9-000348949310200112","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(88)90111-6"},{"key":"bibr10-000348949310200112","doi-asserted-by":"publisher","DOI":"10.3109\/00016487809124717"},{"key":"bibr11-000348949310200112","doi-asserted-by":"publisher","DOI":"10.1121\/1.1906929"},{"key":"bibr12-000348949310200112","doi-asserted-by":"publisher","DOI":"10.1121\/1.1910239"},{"key":"bibr13-000348949310200112","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(90)82644-8"},{"key":"bibr14-000348949310200112","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1992.67.1.108"},{"key":"bibr15-000348949310200112","first-page":"F173","volume":"243","author":"Sterkers O","year":"1982","journal-title":"Am J Physiol"},{"key":"bibr16-000348949310200112","doi-asserted-by":"publisher","DOI":"10.1177\/37.2.2536055"},{"key":"bibr17-000348949310200112","doi-asserted-by":"publisher","DOI":"10.1007\/BF00454128"},{"key":"bibr18-000348949310200112","doi-asserted-by":"publisher","DOI":"10.3109\/00016487309121529"},{"key":"bibr19-000348949310200112","doi-asserted-by":"publisher","DOI":"10.1007\/BF00455206"},{"key":"bibr20-000348949310200112","first-page":"15","volume-title":"Meniere's disease","author":"Kimura RS","year":"1981"}],"container-title":["Annals of Otology, Rhinology & Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348949310200112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348949310200112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:12:32Z","timestamp":1777374752000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348949310200112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1177\/000348949310200112"],"URL":"https:\/\/doi.org\/10.1177\/000348949310200112","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}