{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:47:33Z","timestamp":1777420053505,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1993,2,1]],"date-time":"1993-02-01T00:00:00Z","timestamp":728524800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[1993,2]]},"abstract":"<jats:p>We attempted to determine the relationship of nasal polyps to histamine (HA) metabolism. Compared to that in allergy-related nasal polyps and infection-related nasal polyps, the level of HA in aspirin-induced asthma\u2014related polyps was significantly lower. Large differences between the groups were not observed in HA-synthesizing enzyme activity, but degradative enzyme activity was much higher in aspirin-induced asthma\u2014related polyps than in other types of nasal polyps tested. These findings suggest the possibility that the amount of HA in polyps associated with aspirin-induced asthma was less because of greatly enhanced degradation. We found, in addition, that in nasal tissues such as polyps, histamine- N-methyl transferase, rather than histaminase, was the principal degradative enzyme.<\/jats:p>","DOI":"10.1177\/000348949310200213","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:38:05Z","timestamp":1412347085000},"page":"152-156","source":"Crossref","is-referenced-by-count":3,"title":["Histamine Metabolism in Nasal Polyps"],"prefix":"10.1177","volume":"102","author":[{"given":"Yoshiyuki","family":"Abe","sequence":"first","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Matsunaga","sequence":"additional","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Ogino","sequence":"additional","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morihiro","family":"Irifune","sequence":"additional","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuo","family":"Imamura","sequence":"additional","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamotsu","family":"Harada","sequence":"additional","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Fukui","sequence":"additional","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1993,2,1]]},"reference":[{"key":"bibr1-000348949310200213","first-page":"317","volume":"46","author":"Small P","year":"1981","journal-title":"Ann Allergy"},{"key":"bibr2-000348949310200213","first-page":"631","volume":"29","author":"Caplin I","year":"1971","journal-title":"Ann Allergy"},{"key":"bibr3-000348949310200213","doi-asserted-by":"publisher","DOI":"10.1177\/000348947208100105"},{"key":"bibr4-000348949310200213","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197905000-00023"},{"key":"bibr5-000348949310200213","unstructured":"Ogino S, Harada T, Okawachi I, Irifune M, Matsunaga T, Nagano T. Aspirin-induced asthma and nasal polyps. 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