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For the first 10 years biopsy with radiotherapy was the first-line treatment (n = 20), but for the last 10 years surgical or laser excision biopsy alone has been performed (n = 17). The T stage of the carcinoma in situ does not determine its premalignant potential. Malignancy appears to be a recurrence, rather than a new expression of carcinogenesis. Excision biopsy alone provides local control results (75%) comparable to those of primary radiotherapy (85%). Excision biopsy alone, however, retains the option of subsequent radiotherapy with preservation of laryngeal function, but very close follow-up, especially in the first year, is required.<\/jats:p>","DOI":"10.1177\/000348949310200804","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:38:05Z","timestamp":1412347085000},"page":"592-595","source":"Crossref","is-referenced-by-count":9,"title":["Carcinoma in Situ of the Glottis: Radiotherapy or Excision Biopsy?"],"prefix":"10.1177","volume":"102","author":[{"given":"George E.","family":"Murty","sequence":"first","affiliation":[{"name":"Nottingham, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph P.","family":"Diver","sequence":"additional","affiliation":[{"name":"Nottingham, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick J.","family":"Bradley","sequence":"additional","affiliation":[{"name":"Nottingham, England"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1993,8,1]]},"reference":[{"key":"bibr1-000348949310200804","first-page":"1","volume":"77","author":"Jackson C","year":"1923","journal-title":"Is it preceded by a recognisable precancerous condition? 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