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This report describes the use of recombinant interferon alfa-2a in 15 patients with life-threatening airway hemangiomas. All patients had failed corticosteroid and\/or laser therapy. Multiple upper airway sites were involved, including the base of the tongue, supraglottis, subglottis, trachea, and mediastinum. Eleven patients have completed therapy and are doing well. Four patients have resolving lesions on the drug regimen. Life-threatening airway lesions unresponsive to conventional treatment should be considered for a trial of interferon alfa-2a.<\/jats:p>","DOI":"10.1177\/000348949410300101","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:38:05Z","timestamp":1412347085000},"page":"1-8","source":"Crossref","is-referenced-by-count":79,"title":["Interferon Alfa-2A Therapy for Airway Hemangiomas"],"prefix":"10.1177","volume":"103","author":[{"given":"Laurie A.","family":"Ohlms","sequence":"first","affiliation":[{"name":"Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor J. 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