{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:54:54Z","timestamp":1777420494605,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1995,2,1]],"date-time":"1995-02-01T00:00:00Z","timestamp":791596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[1995,2]]},"abstract":"<jats:p>The vestibular aqueduct of the gerbil has a unique anatomic feature that makes it possible to selectively obliterate the endolymphatic sac with or without interfering with its venous drainage. In animals in which only the endolymphatic sac was ablated, endolymphatic hydrops was slight in the cochlea and was absent in the vestibular labyrinth. The cochlear and vestibular sensory cells were normal. In animals in which both the endolymphatic duct and the vein were obliterated, hydrops was slight, with the exception of a few cochleas that showed moderate hydrops. The sensory cells of the posterior canal cristae had degenerated in all specimens, while varied pathologic changes in cochlear and vestibular sensory cells were present in some specimens. These results suggest that hydrops is primarily due to blockage of the endolymphatic duct and sac and that degeneration of sensory cells occurs when blood flow in the vestibular aqueduct is impeded. Pathologic changes in the endolymphatic sac, including the vascular plexus at the endolymphatic sac, may play an important role in the production of endolymphatic hydrops and vestibular symptoms in Meniere's disease.<\/jats:p>","DOI":"10.1177\/000348949510400213","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:38:05Z","timestamp":1412347085000},"page":"155-160","source":"Crossref","is-referenced-by-count":9,"title":["Degeneration of Vestibular Sensory Cells Caused by Ablation of the Vestibular Aqueduct in the Gerbil Ear"],"prefix":"10.1177","volume":"104","author":[{"given":"Robert S.","family":"Kimura","sequence":"first","affiliation":[{"name":"Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer A.","family":"Trehey","sequence":"additional","affiliation":[{"name":"Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Hutta","sequence":"additional","affiliation":[{"name":"Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1995,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348946707600311"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(83)90119-3"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016486809126300"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016486809120990"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1986.03780040063012"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/00034894840930S407"},{"key":"e_1_2_1_8_2","first-page":"359","article-title":"Obliteration of vestibular and cochlear aqueducts in animals","volume":"84","author":"Suh KW","year":"1977","unstructured":"Suh KW, Cody DTR. Obliteration of vestibular and cochlear aqueducts in animals. Trans Am Acad Ophthalmol Otolaryngol 1977;84: 359\u201379.","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"e_1_2_1_9_2","first-page":"343","article-title":"Membranous hydrops in the inner ear of the guinea pig after obliteration of the endolymphatic sac","volume":"27","author":"Kimura RS","year":"1965","unstructured":"Kimura RS, Schuknecht HF. Membranous hydrops in the inner ear of the guinea pig after obliteration of the endolymphatic sac. Pract Otorhinolaryngol 1965;27: 343\u201354.","journal-title":"Pract Otorhinolaryngol"},{"key":"e_1_2_1_10_2","first-page":"1","article-title":"A study in the comparative anatomy of the blood vascular system of the internal ear in Mammalia and in Homo (Japanese)","volume":"6","author":"Nabeya D","year":"1923","unstructured":"Nabeya D. A study in the comparative anatomy of the blood vascular system of the internal ear in Mammalia and in Homo (Japanese). Kioto Acta Scholae Med 1923;6: 1\u2013132.","journal-title":"Kioto Acta Scholae Med"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348945606500203"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-4-431-68111-3_3"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/003591573803101112"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1959.03010320017005"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00301488"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016486009123121"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016487709123972"},{"key":"e_1_2_1_18_2","first-page":"313","volume-title":"Meniere's disease","author":"Jahnke K","year":"1988","unstructured":"Jahnke K. The ultrastructure of the vestibular end organs in Meniere's disease. In: Nadol JBJr, ed. Meniere's disease. 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