{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:55:12Z","timestamp":1777420512700,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1995,3,1]],"date-time":"1995-03-01T00:00:00Z","timestamp":794016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[1995,3]]},"abstract":"<jats:p>We produced two kinds of experimental endolymphatic hydrops. One was induced by obliteration of the endolymphatic sac (ES), and the other was induced by both systemic keyhole limpet hemocyanin immunization and secondary keyhole limpet hemocyanin challenge into the ES. The vascular permeability of the stria vascularis in acute and chronic phases was compared between both models by light and electron microscopy using the tracer method of horseradish peroxidase. Both models showed that the number of strial capillaries showing horseradish peroxidase leakage was significantly higher in the acute phase than in the chronic phase. In the acute phase, the ES showed acute inflammation in both models. In the chronic phase, extensive fibrosis occurred in the ES obliteration model, whereas the ES appeared to have a normal shape in the immunologically induced model. The mechanism of hydrops formation will be compared between the two models.<\/jats:p>","DOI":"10.1177\/000348949510400306","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:38:05Z","timestamp":1412347085000},"page":"210-217","source":"Crossref","is-referenced-by-count":3,"title":["Vascular Permeability of the Stria Vascularis and Morphology of the Endolymphatic Sac in two Types of Experimental Endolymphatic Hydrops"],"prefix":"10.1177","volume":"104","author":[{"given":"Masafumi","family":"Sakagami","sequence":"first","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Schunichi","family":"Tomiyama","sequence":"additional","affiliation":[{"name":"Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Umemoto","sequence":"additional","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keuiro","family":"Fukazawa","sequence":"additional","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kubo","sequence":"additional","affiliation":[{"name":"Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1995,3,1]]},"reference":[{"key":"bibr1-000348949510400306","first-page":"343","volume":"27","author":"Kimura RS","year":"1965","journal-title":"Pract Otorhinolaryngol"},{"key":"bibr2-000348949510400306","doi-asserted-by":"publisher","DOI":"10.1177\/000348946707600311"},{"key":"bibr3-000348949510400306","doi-asserted-by":"publisher","DOI":"10.1177\/000348948709600309"},{"key":"bibr4-000348949510400306","doi-asserted-by":"publisher","DOI":"10.3109\/00016488809097009"},{"key":"bibr5-000348949510400306","doi-asserted-by":"publisher","DOI":"10.3109\/00016488709107319"},{"key":"bibr6-000348949510400306","doi-asserted-by":"publisher","DOI":"10.1007\/BF00464263"},{"key":"bibr7-000348949510400306","doi-asserted-by":"crossref","unstructured":"Sakagami M, Fukazawa K, Kitamura K, Doi K, Matsunaga T. Vascular permeability of the stria vascularis in experimental endolymphatic hydrops. Acta Otolaryngol [Suppl] (Stockh) 1991(suppl 481): 179\u201381.","DOI":"10.3109\/00016489109131375"},{"key":"bibr8-000348949510400306","doi-asserted-by":"publisher","DOI":"10.3109\/00016489109138424"},{"key":"bibr9-000348949510400306","first-page":"1844","volume":"94","author":"Tomiyama S","year":"1991","journal-title":"J Otolaryngol Jpn"},{"key":"bibr10-000348949510400306","doi-asserted-by":"crossref","unstructured":"Tomiyama S, Nonaka M, Gotou Y, Yagi T. Inner ear damage by local immune response of the endolymphatic sac in the guinea pig. Acta Otolaryngol [Suppl] (Stockh) 1991(suppl 481): 176\u20138.","DOI":"10.3109\/00016489109131374"},{"key":"bibr11-000348949510400306","doi-asserted-by":"publisher","DOI":"10.3109\/00016489209137428"},{"key":"bibr12-000348949510400306","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000390103"},{"key":"bibr13-000348949510400306","unstructured":"Lundquist P-G. The endolymphatic duct and sac in the guinea pig. An electron microscopic and experimental investigation. 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