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We examined 27 cases operated on in our hospital by an in situ hybridization technique to detect their messenger RNA signals in cancer cells and surrounding stroma. Both signals were detected in all cancer nests and in stromal cells in the same specimens. Clinicopathologic studies showed a significant relationship between MMP-2 expression in the primary cancer and the outcome of treatment. Our present study suggests that hypopharyngeal squamous cell carcinoma producing MMP-2 has a high potential for invasion and metastasis and a poor outcome. The analysis of MMPs will be useful for treatment planning in hypopharyngeal carcinoma and for prognosis.<\/jats:p>","DOI":"10.1177\/000348949510400902","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:38:05Z","timestamp":1412347085000},"page":"678-684","source":"Crossref","is-referenced-by-count":60,"title":["Analysis of Expression of Matrix Metalloproteinases-2 and \u22129 in Hypopharyngeal Squamous Cell Carcinoma by in Situ Hybridization"],"prefix":"10.1177","volume":"104","author":[{"given":"Yoshimi","family":"Miyajima","sequence":"first","affiliation":[{"name":"Kurume, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuji","family":"Nakano","sequence":"additional","affiliation":[{"name":"Kitakyushu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Morimatsu","sequence":"additional","affiliation":[{"name":"Kurume, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1995,9,1]]},"reference":[{"key":"bibr1-000348949510400902","doi-asserted-by":"publisher","DOI":"10.2739\/kurumemedj.29.SUPPLEMENT_S97"},{"key":"bibr2-000348949510400902","doi-asserted-by":"publisher","DOI":"10.2468\/jbes.43.88"},{"key":"bibr3-000348949510400902","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197803)41:3<1008::AID-CNCR2820410332>3.0.CO;2-F"},{"key":"bibr4-000348949510400902","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880150507"},{"key":"bibr5-000348949510400902","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19921215)70:12<2747::AID-CNCR2820701204>3.0.CO;2-5"},{"key":"bibr6-000348949510400902","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/99.1.18"},{"key":"bibr7-000348949510400902","first-page":"359","volume":"142","author":"Pyke C","year":"1993","journal-title":"Am J Pathol"},{"key":"bibr8-000348949510400902","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"bibr9-000348949510400902","doi-asserted-by":"crossref","first-page":"6579","DOI":"10.1016\/S0021-9258(18)68680-6","volume":"263","author":"Collier IE","year":"1988","journal-title":"J Biol Chem"},{"key":"bibr10-000348949510400902","doi-asserted-by":"crossref","first-page":"16485","DOI":"10.1016\/S0021-9258(18)55326-6","volume":"266","author":"Huhtala P","year":"1991","journal-title":"J Biol Chem"},{"key":"bibr11-000348949510400902","doi-asserted-by":"crossref","first-page":"17213","DOI":"10.1016\/S0021-9258(18)71480-4","volume":"264","author":"Wilheim SM","year":"1989","journal-title":"J Biol Chem"},{"key":"bibr12-000348949510400902","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.19.5843"},{"key":"bibr13-000348949510400902","first-page":"312","volume":"69","author":"Autio-Harmainen H","year":"1993","journal-title":"Lab Invest"},{"key":"bibr14-000348949510400902","volume-title":"International Union Against Cancer","author":"Hermanek P","year":"1987","edition":"4"},{"key":"bibr15-000348949510400902","first-page":"636","volume":"49","author":"Liotta LA","year":"1983","journal-title":"Lab Invest"},{"key":"bibr16-000348949510400902","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-230X(08)60034-2","volume":"46","author":"Liotta LA","year":"1986","journal-title":"Cancer Res"},{"key":"bibr17-000348949510400902","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910550104"},{"key":"bibr18-000348949510400902","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1993.132"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348949510400902","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348949510400902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:14:46Z","timestamp":1777374886000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348949510400902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,9]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1995,9]]}},"alternative-id":["10.1177\/000348949510400902"],"URL":"https:\/\/doi.org\/10.1177\/000348949510400902","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,9]]}}}