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In the normal tympanic membrane, TGF-\u03b1 expression was not observed, whereas after perforation, over the whole tympanic membrane including the margin of the perforation, TGF-\u03b1-positive cells appeared and were scattered in the epidermal cell layer. After healing of the perforation, a marked decrease of TGF-\u03b1-positive cells in the tympanic membrane was observed. This finding suggests that TGF-\u03b1 induces proliferation of epidermal cells after the perforation stimulus.<\/jats:p>","DOI":"10.1177\/000348949510401008","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:38:05Z","timestamp":1412347085000},"page":"793-797","source":"Crossref","is-referenced-by-count":16,"title":["Immunohistochemical Study of Transforming Growth Factor-\u03b1 Expression in Normal and Perforated Tympanic Membrane"],"prefix":"10.1177","volume":"104","author":[{"given":"Reiko","family":"Koba","sequence":"first","affiliation":[{"name":"Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isuzu","family":"Kawabata","sequence":"additional","affiliation":[{"name":"Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1995,10,1]]},"reference":[{"key":"bibr1-000348949510401008","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510400307"},{"key":"bibr2-000348949510401008","doi-asserted-by":"publisher","DOI":"10.1177\/000348949009900114"},{"key":"bibr3-000348949510401008","doi-asserted-by":"publisher","DOI":"10.3109\/00016489109137397"},{"key":"bibr4-000348949510401008","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-49295-2_4"},{"key":"bibr5-000348949510401008","first-page":"707","volume":"47","author":"Derynck R","year":"1987","journal-title":"Cancer Res"},{"key":"bibr6-000348949510401008","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.2.670"},{"key":"bibr7-000348949510401008","doi-asserted-by":"crossref","first-page":"14408","DOI":"10.1016\/S0021-9258(18)66884-X","volume":"261","author":"Samsoondar J","year":"1986","journal-title":"J Biol Chem"},{"key":"bibr8-000348949510401008","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1242\/dev.114.4.833","volume":"114","author":"Miettinen PJ","year":"1992","journal-title":"Development"},{"key":"bibr9-000348949510401008","doi-asserted-by":"publisher","DOI":"10.1038\/328817a0"},{"key":"bibr10-000348949510401008","doi-asserted-by":"publisher","DOI":"10.1126\/science.3041594"},{"key":"bibr11-000348949510401008","doi-asserted-by":"publisher","DOI":"10.1038\/309804a0"},{"key":"bibr12-000348949510401008","doi-asserted-by":"crossref","first-page":"13614","DOI":"10.1016\/S0021-9258(17)43959-7","volume":"258","author":"Massagu\u00e9 J","year":"1983","journal-title":"J Biol Chem"},{"key":"bibr13-000348949510401008","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041520211"},{"key":"bibr14-000348949510401008","first-page":"341","volume":"52","author":"Stromberg K","year":"1992","journal-title":"Cancer Res"},{"key":"bibr15-000348949510401008","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(05)81572-4"},{"key":"bibr16-000348949510401008","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90591-6"},{"key":"bibr17-000348949510401008","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90179-6"},{"key":"bibr18-000348949510401008","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.8.4001"},{"key":"bibr19-000348949510401008","doi-asserted-by":"publisher","DOI":"10.1126\/science.2422759"},{"key":"bibr20-000348949510401008","first-page":"453","volume-title":"Cellular functions in immunity and inflammation","author":"Wahl SM","year":"1981"},{"key":"bibr21-000348949510401008","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90194-2"},{"key":"bibr22-000348949510401008","first-page":"293","volume":"32","author":"Boedts D","year":"1978","journal-title":"Acta Otorhinolaryngol Belg"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348949510401008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348949510401008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:14:11Z","timestamp":1777374851000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348949510401008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,10]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1995,10]]}},"alternative-id":["10.1177\/000348949510401008"],"URL":"https:\/\/doi.org\/10.1177\/000348949510401008","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,10]]}}}