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For an injection at a constant rate, the endolymph concentration is inversely dependent on the cross-sectional area of the scala into which injection occurred. Marker concentrations were monitored by inserting ion-selective microelectrodes into endolymph near the injection site. In a previous study we quantified the degree of hydrops in animals following ablation of the endolymphatic sac. In the present study we validated the technique by comparing the endolymphatic cross-sectional area measured in vivo with AsF6 with that measured by established histologic procedures. The correlation between the two measures was good, with a coefficient of .903, although the area measured histologically was a little lower than that measured in vivo.<\/jats:p>","DOI":"10.1177\/000348949510401111","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:38:05Z","timestamp":1412347085000},"page":"886-894","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of Endolymph Cross-Sectional Area Measured Histologically with that Measured in Vivo with an Ionic Volume Marker"],"prefix":"10.1177","volume":"104","author":[{"given":"Alec N.","family":"Salt","sequence":"first","affiliation":[{"name":"St Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.","family":"Demott","sequence":"additional","affiliation":[{"name":"St Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Kimura","sequence":"additional","affiliation":[{"name":"Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1995,11,1]]},"reference":[{"key":"bibr1-000348949510401111","first-page":"343","volume":"27","author":"Kimura RS","year":"1965","journal-title":"Pract Otorhinolaryngol"},{"key":"bibr2-000348949510401111","doi-asserted-by":"publisher","DOI":"10.1007\/BF00453674"},{"key":"bibr3-000348949510401111","doi-asserted-by":"publisher","DOI":"10.3109\/00016488609108606"},{"key":"bibr4-000348949510401111","doi-asserted-by":"publisher","DOI":"10.1177\/000348949009900714"},{"key":"bibr5-000348949510401111","doi-asserted-by":"publisher","DOI":"10.1177\/000348947508400301"},{"key":"bibr6-000348949510401111","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(93)90059-A"},{"key":"bibr7-000348949510401111","doi-asserted-by":"publisher","DOI":"10.1177\/019459988709600115"},{"key":"bibr8-000348949510401111","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(94)90184-8"},{"key":"bibr9-000348949510401111","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1073\/pnas.73.5.1761","volume":"76","author":"Feldman AM","year":"1976","journal-title":"Proc Natl Acad Sci USA"},{"key":"bibr10-000348949510401111","doi-asserted-by":"publisher","DOI":"10.1007\/BF00183492"},{"key":"bibr11-000348949510401111","doi-asserted-by":"publisher","DOI":"10.3109\/00206099009072846"},{"key":"bibr12-000348949510401111","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1981.sp013981"},{"key":"bibr13-000348949510401111","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(88)90111-6"},{"key":"bibr14-000348949510401111","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090220205"},{"key":"bibr15-000348949510401111","doi-asserted-by":"publisher","DOI":"10.3109\/00016488109138525"},{"key":"bibr16-000348949510401111","doi-asserted-by":"publisher","DOI":"10.3109\/00206098809081585"},{"key":"bibr17-000348949510401111","first-page":"44","volume-title":"M\u00e9nier\u00e8's disease","author":"Johnstone BM","year":"1981"},{"key":"bibr18-000348949510401111","doi-asserted-by":"publisher","DOI":"10.3109\/00016489209137457"},{"key":"bibr19-000348949510401111","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(94)90044-2"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348949510401111","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348949510401111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:14:17Z","timestamp":1777374857000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348949510401111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,11]]},"references-count":19,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1995,11]]}},"alternative-id":["10.1177\/000348949510401111"],"URL":"https:\/\/doi.org\/10.1177\/000348949510401111","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,11]]}}}