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Clinically, this is usually a glottic neoplasm in which full cordal mobility is still present; early supraglottic cancer is infrequent, and usually a chance finding. Whatever the site, early laryngeal cancer is a minimally invasive neoplastic lesion that does not invade the muscle or cartilage, but is still capable of metastasis. Being confined to the lamina propria, it is more than a carcinoma in situ but less than a deeply infiltrating carcinoma. Superficial extending carcinoma is therefore an early cancer. Biologically, early cancer belongs to stage II.<\/jats:p>","DOI":"10.1177\/000348949610500313","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:38:05Z","timestamp":1412347085000},"page":"245-250","source":"Crossref","is-referenced-by-count":37,"title":["\u201cEarly\u201d Cancer of the Larynx: The Concept as Defined by Clinicians, Pathologists, and Biologists"],"prefix":"10.1177","volume":"105","author":[{"given":"Alfio","family":"Ferlito","sequence":"first","affiliation":[{"name":"Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Carbone","sequence":"additional","affiliation":[{"name":"Aviano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Rinaldo","sequence":"additional","affiliation":[{"name":"Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence W.","family":"Desanto","sequence":"additional","affiliation":[{"name":"Scottsdale, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"D'Angelo","sequence":"additional","affiliation":[{"name":"Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Barnes","sequence":"additional","affiliation":[{"name":"Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth O.","family":"Devaney","sequence":"additional","affiliation":[{"name":"Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1996,3,1]]},"reference":[{"key":"bibr1-000348949610500313","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.45.1.8"},{"key":"bibr2-000348949610500313","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(94)90090-6"},{"key":"bibr3-000348949610500313","first-page":"151","volume-title":"Laryngeal cancer","author":"DeSanto LW","year":"1991"},{"key":"bibr4-000348949610500313","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1994.01880270012003"},{"key":"bibr5-000348949610500313","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(94)90091-4"},{"key":"bibr6-000348949610500313","doi-asserted-by":"publisher","DOI":"10.3109\/00016489509139326"},{"key":"bibr7-000348949610500313","doi-asserted-by":"publisher","DOI":"10.1017\/S002221510009054X"},{"key":"bibr8-000348949610500313","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(83)90243-X"},{"key":"bibr9-000348949610500313","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199102000-00004"},{"key":"bibr10-000348949610500313","unstructured":"Friedmann I, Ferlito A. 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