{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:25Z","timestamp":1777420825093,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1996,5,1]],"date-time":"1996-05-01T00:00:00Z","timestamp":830908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[1996,5]]},"abstract":"<jats:p>The purpose of our study was to elucidate the course of healing of the tympanic membrane (TM) when myringotomy was performed during acute otitis media. The early and long-lasting structural changes of the TM were studied in an animal model. Rats were inoculated with Streptococcus pneumoniae (PnC) type 3 in the bulla. When the infection was manifest, myringotomy was performed. On days 4 and 12, and 3 and 6 months after myringotomy, the TM status was checked by otomicroscopy and TMs were prepared for light and electron microscopy. Comparison was made with PnC-infected TMs that were not perforated, as well as myringotomized noninfected TMs. The infection resolved more slowly in myringotomized ears compared to PnC-infected ears that were left untouched. After 6 months, the pars tensa of the myringotomized infected ears was thickened and showed a disorganized collagen structure, compared with myringotomized noninfected ears, in which TMs were normalized. The PnC-infected TMs without myringotomy were completely normalized after 2 months. We conclude that a combination of bacterial infection and myringotomy causes long-lasting changes in TM structure. This impaired structure of the connective tissue could be of importance in chronic middle ear disease as a presumptive site for retraction and perforation of the TM.<\/jats:p>","DOI":"10.1177\/000348949610500513","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:38:05Z","timestamp":1412347085000},"page":"397-404","source":"Crossref","is-referenced-by-count":23,"title":["Healing of Tympanic Membrane after Myringotomy during\n                    <i>Streptococcus Pneumoniae<\/i>\n                    Otitis Media an Otomicroscopic and Histologic Study in the Rat"],"prefix":"10.1177","volume":"105","author":[{"given":"Karin","family":"Magnuson","sequence":"first","affiliation":[{"name":"Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Hermansson","sequence":"additional","affiliation":[{"name":"Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sten","family":"Hellstr\u00f6m","sequence":"additional","affiliation":[{"name":"Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1996,5,1]]},"reference":[{"key":"bibr1-000348949610500513","doi-asserted-by":"crossref","unstructured":"Ingvarsson L, Lundgren K, Olofsson B, Wall S. Epidemiology of acute otitis media in children. A prospective study of acute otitis media in children. Incidence in an urban population. Acta Otolaryngol [Suppl] (Stockh) 1982(suppl 388): 29\u201352.","DOI":"10.3109\/00016488209123527"},{"key":"bibr2-000348949610500513","doi-asserted-by":"publisher","DOI":"10.3109\/00016488209128938"},{"key":"bibr3-000348949610500513","unstructured":"Prellner K, Kalm O, Harsten G. Middle ear problems in childhood. Acta Otolaryngol [Suppl] (Stockh) 1992(suppl 493): 93\u20138."},{"key":"bibr4-000348949610500513","doi-asserted-by":"publisher","DOI":"10.3109\/inf.1971.3.issue-3.07"},{"key":"bibr5-000348949610500513","doi-asserted-by":"publisher","DOI":"10.1177\/00034894800890S326"},{"key":"bibr6-000348949610500513","doi-asserted-by":"publisher","DOI":"10.3109\/inf.1981.13.issue-3.04"},{"key":"bibr7-000348949610500513","first-page":"37","volume-title":"Treatment of Ear Nose and Throat Infections; workshop","author":"Lundgren K","year":"1985"},{"key":"bibr8-000348949610500513","doi-asserted-by":"publisher","DOI":"10.3109\/00016487909137149"},{"key":"bibr9-000348949610500513","unstructured":"Qvarnberg Y. Acute otitis media. A prospective clinical study of myringotomy and antimicrobial treatment. 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An experimental study [Dissertation]","author":"Von Unge M","year":"1994"},{"key":"bibr30-000348949610500513","doi-asserted-by":"publisher","DOI":"10.1177\/000348949310200912"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348949610500513","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348949610500513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:15:18Z","timestamp":1777374918000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348949610500513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,5]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1996,5]]}},"alternative-id":["10.1177\/000348949610500513"],"URL":"https:\/\/doi.org\/10.1177\/000348949610500513","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,5]]}}}