{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:01:35Z","timestamp":1777420895476,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[1996,8,1]],"date-time":"1996-08-01T00:00:00Z","timestamp":838857600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[1996,8]]},"abstract":"<jats:p>Granulation tissue formation and contraction is inevitable during the healing of open wounds. The presence of infection and a foreign body, such as a silicone airway prosthesis or other tracheotomy tube, magnifies this response. In airway reconstruction, wound contraction secondary to chronic inflammation is a liability. Cultures of granulation tissue were taken from 12 patients with silicone cannulas of T-Tubes. Polymicrobial colonization predominated, with variable combinations of gram-positive, gram-negative, and anaerobic organisms being present. On the basis of sensitivity data, amoxicillin-clavulanate potassium and ciprofloxacin hydrochloride were chosen as empirical antimicrobials. Anecdotally, impressive decreases in the quantity of granulation tissue were seen. We recommend a prospective trial to more accurately define the role of antibiotics in this setting.<\/jats:p>","DOI":"10.1177\/000348949610500807","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:38:05Z","timestamp":1412347085000},"page":"624-627","source":"Crossref","is-referenced-by-count":15,"title":["Microbiology of Tracheal Granulation Tissue Associated with Silicone Airway Prostheses"],"prefix":"10.1177","volume":"105","author":[{"given":"Mark T.","family":"Brown","sequence":"first","affiliation":[{"name":"Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William W.","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1996,8,1]]},"reference":[{"key":"bibr1-000348949610500807","first-page":"9","volume-title":"The molecular and cellular biology of wound repair","author":"Clark RAF","year":"1988"},{"key":"bibr2-000348949610500807","doi-asserted-by":"publisher","DOI":"10.1177\/000348948809700305"},{"key":"bibr3-000348949610500807","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(92)90050-Y"},{"key":"bibr4-000348949610500807","doi-asserted-by":"publisher","DOI":"10.1177\/000348949310200910"},{"key":"bibr5-000348949610500807","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1991.01870170084019"},{"key":"bibr6-000348949610500807","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)36046-5"},{"key":"bibr7-000348949610500807","unstructured":"Montgomery WW. Surgery of the upper respiratory system. Philadelphia, Pa: Lea & Febiger, 1989: 365\u2013520."},{"key":"bibr8-000348949610500807","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197906000-00001"},{"key":"bibr9-000348949610500807","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1177\/000348948509400415","volume":"94","author":"Bellon G","year":"1985","journal-title":"Ann Otol Rhinol Laryngol"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348949610500807","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348949610500807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:15:28Z","timestamp":1777374928000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348949610500807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,8]]},"references-count":9,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1996,8]]}},"alternative-id":["10.1177\/000348949610500807"],"URL":"https:\/\/doi.org\/10.1177\/000348949610500807","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,8]]}}}