{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:18:53Z","timestamp":1792153133568,"version":"4.4.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1997,2,1]],"date-time":"1997-02-01T00:00:00Z","timestamp":854755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[1997,2]]},"abstract":"<jats:p>We report the vestibular abnormalities in 5 patients with the CHARGE association (Coloboma, Heart disease, Atresia of choanae, Retarded growth and development and\/or central nervous system anomalies, Genital hypoplasia, and Ear anomalies). All patients had absent vestibular function as indicated by absent vestibulo-ocular reflexes and severe imbalance on simultaneous deprivation of proprioception and vision, as well as delayed motor development. All 6 semicircular canals were aplastic in each of the patients. While cochlear function was severely reduced in 6 of the 10 ears, it was absent only in 3 ears and was actually intact below 3 kHz in 1 ear. All 10 bony cochleas were present on computed tomography, and although 7 appeared abnormal, 3 appeared normal. This study confirms that absence of the bony semicircular canals in the presence of a bony cochlea is a characteristic finding in CHARGE association. It also demonstrates that these disproportionate structural abnormalities are reflected in the functional abnormalities: absent vestibular function with preservation of some cochlear function.<\/jats:p>","DOI":"10.1177\/000348949710600207","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:38:05Z","timestamp":1412347085000},"page":"129-134","source":"Crossref","is-referenced-by-count":46,"title":["Vestibular Abnormalities in Charge Association"],"prefix":"10.1177","volume":"106","author":[{"given":"Toshihisa","family":"Murofushi","sequence":"first","affiliation":[{"name":"Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert I.","family":"Graham","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Ouvrier","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merl","family":"Da Silva","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey D.","family":"Parker","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Michael","family":"Halmagyi","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1997,2,1]]},"reference":[{"key":"bibr1-000348949710600207","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5234.1212"},{"key":"bibr2-000348949710600207","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5251.586-b"},{"key":"bibr3-000348949710600207","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80513-2"},{"key":"bibr4-000348949710600207","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80454-4"},{"key":"bibr5-000348949710600207","doi-asserted-by":"publisher","DOI":"10.1177\/000348948609500509"},{"key":"bibr6-000348949710600207","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1993.01880130051006"},{"key":"bibr7-000348949710600207","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.25.3.147"},{"key":"bibr8-000348949710600207","doi-asserted-by":"publisher","DOI":"10.1177\/019459988509300619"},{"key":"bibr9-000348949710600207","unstructured":"Rudge P. Clinical neuro-otology. Edinburgh, Scotland: Churchill Livingstone, 1983: 63\u201397."},{"key":"bibr10-000348949710600207","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520310043015"},{"key":"bibr11-000348949710600207","unstructured":"Baloh RW, Honrubia V. Clinical neurophysiology of the vestibular system. 2nd ed. Philadelphia, Pa: FA Davis, 1990: 112\u201329."},{"key":"bibr12-000348949710600207","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(72)80575-4"},{"key":"bibr13-000348949710600207","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1972.00770080222009"},{"key":"bibr14-000348949710600207","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1987.01860030097017"},{"key":"bibr15-000348949710600207","doi-asserted-by":"publisher","DOI":"10.1002\/lary.5540971301"},{"key":"bibr16-000348949710600207","doi-asserted-by":"publisher","DOI":"10.1177\/000348949009901205"},{"key":"bibr17-000348949710600207","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100120067"},{"key":"bibr18-000348949710600207","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1515\/9789882200340-022","volume-title":"Basic and applied aspects of vestibular function","author":"Suzuki JI","year":"1988"},{"key":"bibr19-000348949710600207","doi-asserted-by":"crossref","unstructured":"Magnusson M, Enbom H, Pyykk\u00f6 I. Postural compensation of congenital or early acquired vestibular loss in hearing disabled children. Acta Otolaryngol Suppl (Stockh) 1991(suppl 481): 433\u20135.","DOI":"10.3109\/00016489109131439"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348949710600207","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348949710600207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:15:52Z","timestamp":1777374952000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348949710600207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,2]]}},"alternative-id":["10.1177\/000348949710600207"],"URL":"https:\/\/doi.org\/10.1177\/000348949710600207","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,2]]}}}