{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:04:00Z","timestamp":1777421040959,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[1997,12,1]],"date-time":"1997-12-01T00:00:00Z","timestamp":880934400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[1997,12]]},"abstract":"<jats:p>The in vivo effect of systemic administration of monoclonal antibody (mAb) against ICAM-1 (\u03b1ICAM-1) in experimental immune-mediated labyrinthitis was evaluated. The \u03b1ICAM-1\u2013treated rats showed reduced inflammatory cell infiltration in the scala tympani and the perisaccular tissue of the endolymphatic sac. However, with this experimental paradigm, labyrinthitis could not be completely abolished. These findings suggest that ICAM-1\u2013dependent pathways play an important role in the series of immunologic events occurring in the inner ear, and that the use of ICAM-1 antagonist may be a possible therapeutic approach to labyrinthitis.<\/jats:p>","DOI":"10.1177\/000348949710601211","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:38:05Z","timestamp":1412347085000},"page":"1070-1075","source":"Crossref","is-referenced-by-count":11,"title":["Reduction of Inner Ear Inflammation by Treatment with Anti-ICAM-1 Antibody"],"prefix":"10.1177","volume":"106","author":[{"given":"Tsuyoshi","family":"Takasu","sequence":"first","affiliation":[{"name":"Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey P.","family":"Harris","sequence":"additional","affiliation":[{"name":"San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1997,12,1]]},"reference":[{"key":"bibr1-000348949710601211","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198810000-00018"},{"key":"bibr2-000348949710601211","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199010000-00001"},{"key":"bibr3-000348949710601211","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199308000-00010"},{"key":"bibr4-000348949710601211","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510400111"},{"key":"bibr5-000348949710601211","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830180107"},{"key":"bibr6-000348949710601211","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.4049\/jimmunol.144.12.4604","volume":"144","author":"Cosimi AB","year":"1990","journal-title":"J Immunol"},{"key":"bibr7-000348949710601211","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1991.14"},{"key":"bibr8-000348949710601211","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.3.667"},{"key":"bibr9-000348949710601211","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.45.1.361"},{"key":"bibr10-000348949710601211","doi-asserted-by":"publisher","DOI":"10.1177\/019459988309100105"},{"key":"bibr11-000348949710601211","doi-asserted-by":"publisher","DOI":"10.1177\/000348948409300211"},{"key":"bibr12-000348949710601211","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/2.2.165"},{"key":"bibr13-000348949710601211","doi-asserted-by":"crossref","first-page":"245","DOI":"10.4049\/jimmunol.137.1.245","volume":"137","author":"Dustin ML","year":"1986","journal-title":"J Immunol"},{"key":"bibr14-000348949710601211","doi-asserted-by":"publisher","DOI":"10.3109\/00016488909107394"},{"key":"bibr15-000348949710601211","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-2494(93)80058-7"},{"key":"bibr16-000348949710601211","doi-asserted-by":"publisher","DOI":"10.1084\/jem.141.1.138"},{"key":"bibr17-000348949710601211","doi-asserted-by":"publisher","DOI":"10.1038\/346425a0"},{"key":"bibr18-000348949710601211","doi-asserted-by":"publisher","DOI":"10.3109\/00016488609119418"},{"key":"bibr19-000348949710601211","doi-asserted-by":"publisher","DOI":"10.1177\/000348949009901206"},{"key":"bibr20-000348949710601211","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199304000-00016"},{"key":"bibr21-000348949710601211","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370703"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348949710601211","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348949710601211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:15:49Z","timestamp":1777374949000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348949710601211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,12]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1997,12]]}},"alternative-id":["10.1177\/000348949710601211"],"URL":"https:\/\/doi.org\/10.1177\/000348949710601211","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,12]]}}}