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Normal control biopsy specimens were obtained from children with no history of ear, nose, or throat infections. The results show a significant increase in the germinal center area in tonsils exhibiting hypertrophy when compared to normal controls (p &lt; .002). Image analysis is an important tool for making quantitative size comparisons in lymphoid tissues.<\/jats:p>","DOI":"10.1177\/000348949910800414","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:38:05Z","timestamp":1412347085000},"page":"398-402","source":"Crossref","is-referenced-by-count":12,"title":["Quantitative Study of Germinal Center Area in Normal and Diseased Tonsils Using Image Analysis"],"prefix":"10.1177","volume":"108","author":[{"given":"Janet L.","family":"Gorfien","sequence":"first","affiliation":[{"name":"Buffalo, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Hard","sequence":"additional","affiliation":[{"name":"Buffalo, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernice","family":"Noble","sequence":"additional","affiliation":[{"name":"Buffalo, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Brodsky","sequence":"additional","affiliation":[{"name":"Buffalo, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1999,4,1]]},"reference":[{"key":"bibr1-000348949910800414","first-page":"63","volume-title":"Immunology of the ear","author":"Brandtzaeg P","year":"1987"},{"key":"bibr2-000348949910800414","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198810000-00006"},{"key":"bibr3-000348949910800414","doi-asserted-by":"crossref","unstructured":"Perry ME, Jones MM, Mustafa Y. Structure of the crypt epithelium in human palatine tonsils. Acta Otolaryngol Suppl (Stockh) 1988(suppl 454): 53\u20139.","DOI":"10.3109\/00016488809125005"},{"key":"bibr4-000348949910800414","first-page":"7","volume":"100","author":"Favre A","year":"1986","journal-title":"J Mikrosk Anat Forsch"},{"key":"bibr5-000348949910800414","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1288\/00005537-198801000-00019","volume":"98","author":"Brodsky L","year":"1988","journal-title":"Laryngoscope"},{"key":"bibr6-000348949910800414","unstructured":"Brodsky L, Frankel SS, Gorfien J, Rosman J, Noble B. The role of dendritic cells in the development of chronic tonsillar disease in children. 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