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The goal of the study was to evaluate the relationship between glycemia and blood spectroscopic variables in an experimental model of type 1 diabetes (streptozotocin model). Blood samples were taken weekly (10 weeks) from the tail of male Wistar rats with or without diabetes. Blood optical absorption spectra were obtained by means of photoacoustic spectroscopy. It was possible to estimate the time-course of blood characteristic peak ratios. The area under the curve of those peaks correlated with hyperglycemia. The evolution of the optical absorption at 450\u2009nm, related to cytochrome p450, was obtained by using the phase-resolved method. The area under the curve of p450 correlated also with hyperglycemia. It is concluded that photoacoustic spectroscopy is a reliable technology to detect the effects of hyperglycemia on blood with possible applications in the study of long-term diabetes complications.<\/jats:p>","DOI":"10.1177\/00037028211047257","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T10:21:52Z","timestamp":1633083712000},"page":"1465-1474","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Photoacoustic Spectroscopy and Hyperglycemia in Experimental Type 1 Diabetes"],"prefix":"10.1177","volume":"75","author":[{"given":"Lilia I.","family":"Olvera Cano","sequence":"first","affiliation":[{"name":"Instituto Polit\u00e9cnico Nacional, Escuela Superior de F\u00edsica y Matem\u00e1ticas, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe C.","family":"Villanueva Lopez","sequence":"additional","affiliation":[{"name":"Instituto Polit\u00e9cnico Nacional, Escuela Superior de Medicina, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn Romero","family":"Mateos","sequence":"additional","affiliation":[{"name":"Instituto Polit\u00e9cnico Nacional, Escuela Superior de Medicina, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4329-5449","authenticated-orcid":false,"given":"Alfredo Cruz","family":"Orea","sequence":"additional","affiliation":[{"name":"Departamento de F\u00edsica, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,10,1]]},"reference":[{"key":"bibr1-00037028211047257","unstructured":"World Health Organization (WHO). \u201cGlobal Report on Diabetes\u201d. 2016. https:\/\/www.who.int\/publications\/i\/item\/9789241565257 [accessed Aug 27 2021]."},{"key":"bibr2-00037028211047257","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-S062"},{"key":"bibr3-00037028211047257","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.03.024"},{"key":"bibr4-00037028211047257","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1977.tb15131.x"},{"key":"bibr5-00037028211047257","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2003.01065.x"},{"issue":"16","key":"bibr6-00037028211047257","first-page":"2183","volume":"131","author":"Tesch G.H.","year":"2017","journal-title":"Sci."},{"key":"bibr7-00037028211047257","doi-asserted-by":"publisher","DOI":"10.1007\/s10765-012-1304-z"},{"key":"bibr8-00037028211047257","doi-asserted-by":"publisher","DOI":"10.1088\/1742-6596\/1221\/1\/012070"},{"key":"bibr9-00037028211047257","doi-asserted-by":"publisher","DOI":"10.1063\/1.322296"},{"key":"bibr10-00037028211047257","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1981.tb09074.x"},{"key":"bibr11-00037028211047257","doi-asserted-by":"publisher","DOI":"10.1016\/j.pacs.2018.05.001"},{"issue":"1","key":"bibr12-00037028211047257","first-page":"53","volume":"1","author":"Newcomer E.","year":"2020","journal-title":"Fertil. 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