{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:27:55Z","timestamp":1777433275183,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:p>Increased numbers of requests for serological investigation of coeliac disease, and a local trend to request both anti-gliadin antibodies (AGA) and anti-endomysium antibodies (AEA) simultaneously, resulted in cost pressures that prompted a review of our practice. Serology results from all patients (771 children, 511 adults) investigated for coeliac disease over a 3-year period were compared with small intestine histology where available. IgG AGA and IgA AGA were measured by enzyme-linked immunosorbent assay (in-house), IgA AEA by immunofluorescence (send-away contract). Overall diagnostic performance was as follows: AGA sensitivity 84%, specificity 88%, positive predictive value (PPV) 24%, negative predictive value (NPV) 99%; AEA sensitivity 88%, specificity 97%, PPV 65%, NPV 99%.<\/jats:p>\n                  <jats:p>Results showed AGA, with its high NPV, to be a suitable first-line test to exclude coeliac disease. The high specificity of AEA makes it a suitable confirmatory test when AGA is positive. Introduction of this step-wise approach to coeliac disease investigation resulted in cost savings of at least \u00a35000 per year without detriment to the clinical service.<\/jats:p>","DOI":"10.1177\/000456320003700406","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:51:35Z","timestamp":1391619095000},"page":"467-470","source":"Crossref","is-referenced-by-count":4,"title":["Cost-Effective Strategy for the Serological Investigation of Coeliac Disease"],"prefix":"10.1177","volume":"37","author":[{"given":"A","family":"Bowron","sequence":"first","affiliation":[{"name":"Department of Chemical Pathology, Bristol Royal Infirmary, Bristol BS2 8HW, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Moorghen","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Bristol Royal Infirmary, Bristol BS2 8HW, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J E","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology, Bristol Royal Infirmary, Bristol BS2 8HW, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J R","family":"Osborne","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology, Bristol Royal Infirmary, Bristol BS2 8HW, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Stansbie","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology, Bristol Royal Infirmary, Bristol BS2 8HW, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J E","family":"Stone","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology, Bristol Royal Infirmary, Bristol BS2 8HW, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,7,1]]},"reference":[{"key":"bibr1-000456320003700406","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.319.7204.236"},{"key":"bibr2-000456320003700406","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7177.164"},{"key":"bibr3-000456320003700406","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.8.909"},{"key":"bibr4-000456320003700406","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.49.9.704"},{"key":"bibr5-000456320003700406","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.303.6811.1163"},{"key":"bibr6-000456320003700406","doi-asserted-by":"publisher","DOI":"10.1177\/000456329803500317"},{"key":"bibr7-000456320003700406","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92893-M"},{"key":"bibr8-000456320003700406","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1994.tb06018.x"},{"key":"bibr9-000456320003700406","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70007-1"},{"key":"bibr10-000456320003700406","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70410-5"},{"key":"bibr11-000456320003700406","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70172-0"},{"key":"bibr12-000456320003700406","volume-title":"Anti-gliadin antibodies and coeliac disease [MSc dissertation]","author":"Morgan JE","year":"1992"},{"key":"bibr13-000456320003700406","unstructured":"Jones R, Payne B. 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