{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:38:03Z","timestamp":1793277483010,"version":"4.5.0"},"reference-count":62,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2001,9,1]],"date-time":"2001-09-01T00:00:00Z","timestamp":999302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:p>Procalcitonin is a 14-kDa protein encoded by the Calc-I gene along with calcitonin and katacalcin. The function and regulation of this protein are quite different from those of the other gene products. Blood concentrations of procalcitonin are increased in systemic inflammation, especially when this is caused by bacterial infection. Studies of its behaviour in patients with bacterial sepsis have led to the proposal that it may be a useful marker of systemic bacterial infection, with greater specificity and sensitivity than acute phase proteins such as C-reactive protein.<\/jats:p>","DOI":"10.1177\/000456320103800505","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:51:35Z","timestamp":1391619095000},"page":"483-493","source":"Crossref","is-referenced-by-count":111,"title":["Procalcitonin as an Acute Phase Marker"],"prefix":"10.1177","volume":"38","author":[{"given":"John","family":"Whicher","sequence":"first","affiliation":[{"name":"Division of Clinical Sciences, University of Leeds, Leeds LS2 9JT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Bienvenu","sequence":"additional","affiliation":[{"name":"Laboratoire d'Immunologie, Centre Hospitalier Lyon-Sud, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Monneret","sequence":"additional","affiliation":[{"name":"Laboratoire d'Immunologie, Centre Hospitalier Lyon-Sud, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2001,9,1]]},"reference":[{"key":"bibr1-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199206000-00025"},{"key":"bibr2-000456320103800505","first-page":"103","volume-title":"Recent Advances in Clinical Biochemistry","volume":"3","author":"Laurell C-B.","year":"1985"},{"key":"bibr3-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(84)80839-X"},{"key":"bibr4-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/17.17.6999"},{"key":"bibr5-000456320103800505","doi-asserted-by":"crossref","first-page":"7943","DOI":"10.1016\/S0021-9258(18)42603-8","volume":"267","author":"Adema GJ","year":"1992","journal-title":"J Biol Chem"},{"key":"bibr6-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1038\/298240a0"},{"key":"bibr7-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1038\/305534a0"},{"key":"bibr8-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1159\/000026321"},{"key":"bibr9-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1038\/304129a0"},{"key":"bibr10-000456320103800505","first-page":"1605","volume":"79","author":"Dandona P","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"bibr11-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90277-N"},{"key":"bibr12-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1042\/bj2560245"},{"key":"bibr13-000456320103800505","doi-asserted-by":"crossref","first-page":"14386","DOI":"10.1016\/S0021-9258(18)66881-4","volume":"261","author":"Gkonos PJ","year":"1986","journal-title":"J Biol Chem"},{"key":"bibr14-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)43228-5"},{"key":"bibr15-000456320103800505","first-page":"812","volume":"46","author":"Cate CC","year":"1986","journal-title":"Cancer Res"},{"key":"bibr16-000456320103800505","first-page":"89","volume":"89","author":"Becker KL","year":"1978","journal-title":"Acta Endocrinol"},{"key":"bibr17-000456320103800505","first-page":"196","volume":"104","author":"Becker KL","year":"1980","journal-title":"Arch Pathol Lab Med"},{"key":"bibr18-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2143(99)90053-7"},{"key":"bibr19-000456320103800505","first-page":"11","volume":"203","author":"Russwurm S","year":"1999","journal-title":"Z Geburtsh Neonatol"},{"key":"bibr20-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1016\/S0883-9441(99)90005-9"},{"key":"bibr21-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1007\/BF02565168"},{"key":"bibr22-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200002000-00028"},{"key":"bibr23-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200004000-00021"},{"key":"bibr24-000456320103800505","first-page":"S171","volume":"32","author":"Schmidt J","year":"1997","journal-title":"An\u00e4sthesiol Intensivmed Notfallmed Schmerzther"},{"key":"bibr25-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199806000-00015"},{"key":"bibr26-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.1999.119"},{"key":"bibr27-000456320103800505","first-page":"6845","volume":"49","author":"Ghillani PP","year":"1989","journal-title":"Cancer Res"},{"key":"bibr28-000456320103800505","unstructured":"Meisner M. PCT - procalcitonin. A new and innovative parameter in diagnosis of infections. Berlin: Brahms Diagnostica, 1996: 14\u201360."},{"key":"bibr29-000456320103800505","first-page":"597","volume":"35","author":"Meisner M","year":"1997","journal-title":"Eur J Clin Chem Clin Biochem"},{"key":"bibr30-000456320103800505","first-page":"118","volume":"12","author":"Monneret G","year":"1997","journal-title":"Immunoanalt Biol Sp\u00e9c"},{"key":"bibr31-000456320103800505","first-page":"294","author":"Mallet E","journal-title":"Lancet"},{"key":"bibr32-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050543"},{"key":"bibr33-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1159\/000018625"},{"key":"bibr34-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050644"},{"key":"bibr35-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1010251"},{"key":"bibr36-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199807000-00016"},{"key":"bibr37-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.1999.048"},{"key":"bibr38-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1003354"},{"key":"bibr39-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1016\/0954-6111(95)90069-1"},{"key":"bibr40-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9629(15)41740-9"},{"key":"bibr41-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199704000-00009"},{"key":"bibr42-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.1999.060"},{"key":"bibr43-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1007\/s004230050170"},{"key":"bibr44-000456320103800505","first-page":"331","volume":"1","author":"Al-Nawas B","year":"1996","journal-title":"Eur J Med Res"},{"key":"bibr45-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199903000-00024"},{"key":"bibr46-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200004000-00011"},{"key":"bibr47-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200004000-00007"},{"key":"bibr48-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.1998.012"},{"key":"bibr49-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70374-8"},{"key":"bibr50-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1997.tb08870.x"},{"key":"bibr51-000456320103800505","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1093\/clinchem\/44.6.1343","volume":"44","author":"Sachse C","year":"1998","journal-title":"Clin Chem"},{"key":"bibr52-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1086\/514576"},{"key":"bibr53-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1086\/517758"},{"key":"bibr54-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)79165-0"},{"key":"bibr55-000456320103800505","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1093\/clinchem\/45.3.440","volume":"45","author":"Martin-Denavit T","year":"1999","journal-title":"Clin Chem"},{"key":"bibr56-000456320103800505","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1093\/clinchem\/46.10.1583","volume":"46","author":"Assuma M","year":"2000","journal-title":"Clin Chem"},{"key":"bibr57-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1086\/513633"},{"key":"bibr58-000456320103800505","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1399-0012.1998.tb01092.x","volume":"12","author":"Eberhard OK","year":"1998","journal-title":"Clin Transplant"},{"key":"bibr59-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(96)00314-4"},{"key":"bibr60-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-3274(98)80013-0"},{"key":"bibr61-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(98)00667-8"},{"key":"bibr62-000456320103800505","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.1998.tb00050.x"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456320103800505","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456320103800505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:51:28Z","timestamp":1777377088000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000456320103800505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9]]},"references-count":62,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,9]]}},"alternative-id":["10.1177\/000456320103800505"],"URL":"https:\/\/doi.org\/10.1177\/000456320103800505","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,9]]}}}