{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:31:09Z","timestamp":1791088269823,"version":"4.1.0"},"reference-count":9,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,9,30]],"date-time":"2013-09-30T00:00:00Z","timestamp":1380499200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Familial lipoprotein lipase (LPL) deficiency is a very rare autosomal recessive disorder characterized by marked elevation of plasma triglyceride concentrations. Since 1989, a variety of mutations have been reported in affected patients. Studies on subjects with heterozygous LPL deficiency, on the other hand, have been limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We examined post-heparin plasma LPL activity in 15 subjects with heterozygous LPL deficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The heterozygotes exhibited normal or slightly elevated plasma triglyceride concentrations. The mean LPL activity was reduced by 25% in the heterozygotes relative to controls. Interestingly, LPL activity was reduced specifically in female heterozygotes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LPL activity is decreased in female, but not in male, subjects heterozygous for a number of different LPL gene mutations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0004563213498711","type":"journal-article","created":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T03:33:54Z","timestamp":1380598434000},"page":"294-297","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Lipoprotein lipase activity in heterozygotes for lipoprotein lipase gene mutations reveals a gender bias"],"prefix":"10.1177","volume":"51","author":[{"given":"Toshio","family":"Murase","sequence":"first","affiliation":[{"name":"Okinaka Memorial Institute for Medical Research, Tokyo, Japan"},{"name":"Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsu","family":"Ebara","sequence":"additional","affiliation":[{"name":"Okinaka Memorial Institute for Medical Research, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Okubo","sequence":"additional","affiliation":[{"name":"Okinaka Memorial Institute for Medical Research, Tokyo, Japan"},{"name":"Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,9,30]]},"reference":[{"key":"bibr1-0004563213498711","first-page":"2789","volume-title":"The metabolic and molecular bases of inherited disease","author":"Brunzell JD","year":"2001","edition":"8"},{"key":"bibr2-0004563213498711","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(80)90112-2"},{"key":"bibr3-0004563213498711","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115507"},{"key":"bibr4-0004563213498711","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4439(92)90015-F"},{"key":"bibr5-0004563213498711","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00008-8"},{"key":"bibr6-0004563213498711","doi-asserted-by":"publisher","DOI":"10.5551\/jat1994.7.45"},{"key":"bibr7-0004563213498711","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.3.948"},{"key":"bibr8-0004563213498711","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)42026-7"},{"key":"bibr9-0004563213498711","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/41.1.121"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0004563213498711","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0004563213498711","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0004563213498711","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:21:28Z","timestamp":1777378888000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0004563213498711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,30]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1177\/0004563213498711"],"URL":"https:\/\/doi.org\/10.1177\/0004563213498711","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,30]]}}}