{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:47:32Z","timestamp":1790059652007,"version":"4.0.1"},"reference-count":10,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T00:00:00Z","timestamp":1384992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This article describes three patients in whom measured serum testosterone concentrations were found to be artifactually high due to interference from norethisterone medication. This interference was investigated further by distributing samples containing norethisterone through an external quality assessment scheme.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum samples containing different concentrations of norethisterone were distributed to participants in the UK external quality assessment scheme (UK NEQAS) for female testosterone in order to assess the degree of interference from norethisterone in different commercially available immunoassay and liquid chromatography-tandem mass spectrometry methods for measurement of testosterone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results have shown that apparent serum testosterone concentrations in excess of 5\u2009nmol\/L may be obtained using the Roche E170 Modular immunoassay method for samples collected from patients taking norethisterone medication and this interference can be reproduced by adding norethisterone to serum samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although the biggest interference is seen with the Roche system, there is a small effect in the Siemens ADVIA Centaur assay and some of the other immunoassays may also be affected to a much lesser extent. Norethisterone does not interfere in testosterone measurements obtained by liquid chromatography-tandem mass spectrometry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0004563213512800","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T23:27:55Z","timestamp":1385076475000},"page":"284-288","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Norethisterone interference in testosterone assays"],"prefix":"10.1177","volume":"51","author":[{"given":"Jinny","family":"Jeffery","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, Derriford Hospital, Plymouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finlay","family":"MacKenzie","sequence":"additional","affiliation":[{"name":"University Hospitals Birmingham, UK NEQAS, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoff","family":"Beckett","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Royal Infirmary of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Les","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Croydon University Hospital, Surrey, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Ayling","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Derriford Hospital, Plymouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,11,21]]},"reference":[{"key":"bibr1-0004563213512800","first-page":"105","volume":"25","author":"Tate J","year":"2004","journal-title":"Clin Biochem Rev"},{"key":"bibr2-0004563213512800","doi-asserted-by":"publisher","DOI":"10.1373\/49.8.1250"},{"key":"bibr3-0004563213512800","doi-asserted-by":"publisher","DOI":"10.1258\/000456306776865106"},{"key":"bibr4-0004563213512800","doi-asserted-by":"publisher","DOI":"10.1258\/000456306776865034"},{"key":"bibr5-0004563213512800","doi-asserted-by":"crossref","unstructured":"Srikugan L, Sankaralingam A and McGowan B. First case report of testosterone assay-interference in a female taking maca (\n                      Lepidium meyenii\n                      )\n                      . BMJ Case Reports.\n                      Epub ahead of print 28 March 2011. DOI: 10.1136\/bcr.01.2011.3781.","DOI":"10.1136\/bcr.01.2011.3781"},{"key":"bibr6-0004563213512800","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.158600"},{"key":"bibr7-0004563213512800","first-page":"P107","volume":"12","author":"Ravikumar B","year":"2006","journal-title":"Endocrine Abstracts"},{"key":"bibr8-0004563213512800","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(87)90083-7"},{"key":"bibr9-0004563213512800","unstructured":"Primulut N. Package insert, Schering (Pty) Ltd, http:\/\/home.intekom.com\/pharm\/schering\/primlutn.html (2005, accessed December 2011)."},{"key":"bibr10-0004563213512800","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(82)90078-6"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0004563213512800","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0004563213512800","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0004563213512800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:21:38Z","timestamp":1777378898000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0004563213512800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,21]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1177\/0004563213512800"],"URL":"https:\/\/doi.org\/10.1177\/0004563213512800","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,21]]}}}