{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:11:49Z","timestamp":1785773509251,"version":"3.56.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitamin D deficiency is increasingly recognized in patients with primary hyperparathyroidism but some clinicians are reluctant to replace vitamin D due to concerns with aggravating hypercalcaemia. We investigated the impact of vitamin D repletion in asymptomatic patients with normocalcaemic and hypercalcaemic primary hyperparathyroidism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective analysis of 111 patients with elevated parathyroid hormone concentrations (&gt;6.4\u2009pmol\/L) referred to our endocrine clinic between January and December 2012; we identified 39 patients with primary hyperparathyroidism and vitamin D deficiency, i.e. 25 hydroxy vitamin D &lt;20\u2009 \u00b5g\/L. Patients were categorized into normocalcaemic (n\u2009=\u200923) and hypercalcaemic (n\u2009=\u200916) groups and the impact on biochemical parameters was recorded after at least six months treatment with either 1600 or 3200\u00a0units daily of cholecalciferol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both normocalcaemic and hypercalcaemic groups showed a rise in 25 hydroxy vitamin D concentrations after replacement (p &lt;0.0001). Parathyroid hormone concentrations fell in the normocalcaemic group (p\u2009=\u20090.08) but individually, five patients showed a rise (8\u201338% of baseline). In the hypercalcaemic group, parathyroid hormone remained static but the adjusted calcium concentration fell significantly (p\u2009=\u20090.006) except in two patients who showed mild rises (3 and 6%, respectively). There was no deterioration in renal function or calcium-related adverse events in any of the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study supports the safety of vitamin D replacement in patients with mild asymptomatic primary hyperparathyroidism and coexistent vitamin D deficiency. Repletion does not aggravate hypercalcaemia and may limit disease progression. Patients with normocalcaemic primary hyperparathyroidism need further characterization from longitudinal studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0004563214564400","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T01:02:23Z","timestamp":1417568543000},"page":"462-469","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Impact of vitamin D replacement in patients with normocalcaemic and hypercalcaemic primary hyperparathyroidism and coexisting vitamin D deficiency"],"prefix":"10.1177","volume":"52","author":[{"given":"Gautam","family":"Das","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Prince Charles Hospital, Cwm Taf University Health Board, Merthyr Tydfil, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Eligar","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University Hospital of Wales, Cardiff and Vale University Health Board, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyothish","family":"Govindan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University Hospital of Wales, Cardiff and Vale University Health Board, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LNR","family":"Bondugulapati","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University Hospital of Wales, Cardiff and Vale University Health Board, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onyebuchi","family":"Okosieme","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Prince Charles Hospital, Cwm Taf University Health Board, Merthyr Tydfil, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University Hospital of Wales, Cardiff and Vale University Health Board, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"bibr1-0004563214564400","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.07s202"},{"key":"bibr2-0004563214564400","first-page":"1054","volume":"85","author":"Rao DS","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"bibr3-0004563214564400","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00294-6"},{"key":"bibr4-0004563214564400","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1992.tb02278.x"},{"key":"bibr5-0004563214564400","first-page":"209","volume":"82","author":"Davies M","year":"1997","journal-title":"Implications for metabolic bone disease. J Clin Endocrinol Metab"},{"key":"bibr6-0004563214564400","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)78933-9"},{"key":"bibr7-0004563214564400","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021404"},{"key":"bibr8-0004563214564400","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031014"},{"key":"bibr9-0004563214564400","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-67-6-1294"},{"key":"bibr10-0004563214564400","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27302010000200004"},{"key":"bibr11-0004563214564400","doi-asserted-by":"crossref","first-page":"N57","DOI":"10.1359\/jbmr.2002.17.4.563","volume":"17","author":"Bilezikian JP","year":"2002","journal-title":"J Bone Miner Res"},{"key":"bibr12-0004563214564400","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(05)70146-8"},{"key":"bibr13-0004563214564400","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)91333-X"},{"key":"bibr14-0004563214564400","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(74)90812-2"},{"key":"bibr15-0004563214564400","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)06176-4"},{"key":"bibr16-0004563214564400","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1772"},{"key":"bibr17-0004563214564400","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2008.06.032"},{"key":"bibr18-0004563214564400","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0901"},{"key":"bibr19-0004563214564400","doi-asserted-by":"publisher","DOI":"10.4158\/EP12155.OR"},{"key":"bibr20-0004563214564400","doi-asserted-by":"publisher","DOI":"10.1530\/EC-12-0008"},{"key":"bibr21-0004563214564400","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12398"},{"key":"bibr22-0004563214564400","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1454"},{"key":"bibr23-0004563214564400","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1758"},{"key":"bibr24-0004563214564400","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2802"},{"key":"bibr25-0004563214564400","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-009-9211-1"},{"key":"bibr26-0004563214564400","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6161.450"},{"key":"bibr27-0004563214564400","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1977.tb03370.x"},{"key":"bibr28-0004563214564400","first-page":"3541","volume":"85","author":"Kantorovich V","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"bibr29-0004563214564400","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02371.x"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0004563214564400","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0004563214564400","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0004563214564400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:22:01Z","timestamp":1777378921000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0004563214564400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,2]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1177\/0004563214564400"],"URL":"https:\/\/doi.org\/10.1177\/0004563214564400","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,2]]}}}