{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T19:49:43Z","timestamp":1793821783289,"version":"4.6.1"},"reference-count":36,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T00:00:00Z","timestamp":1431561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Microbiological culture of cerebrospinal fluid is the gold standard to differentiate between aseptic and bacterial meningitis, but this method has low sensitivity. A fast and reliable new marker would be of interest in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Interleukin-6, secreted by T cells in response to meningeal pathogens and quickly delivered into cerebrospinal fluid, was evaluated as a marker of acute meningitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and Methods<\/jats:title>\n                    <jats:p>A total of 150 cerebrospinal fluid samples were analysed by an electrochemiluminescence method, selected according to patient diagnosis: (a) bacterial meningitis confirmed by positive culture ( n\u2009=\u200926); (b) bacterial meningitis with negative culture or not performed ( n\u2009=\u200915); (c) viral meningitis confirmed by polymerase chain reaction or immunoglobulin G determination ( n\u2009=\u200923); (d) viral meningitis with polymerase chain reaction negative or not performed ( n\u2009=\u200942); and (e) controls ( n\u2009=\u200944).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cerebrospinal fluid interleukin-6 concentration showed significant differences between all pathologic groups and the control group ( P\u2009&lt;\u20090.001). As a diagnostic tool for bacterial meningitis, interleukin-6 showed an area under the curve of 0.937 (95% confidence intervals: 0.895\u20130.978), significantly higher than those of classical biomarkers. An interleukin-6 cutoff of 1418\u2009pg\/mL showed 95.5% sensitivity and 77.5% specificity, whereas a value of 15,060\u2009pg\/mL showed 63.6% sensitivity and 96.7% specificity, for diagnosis of bacterial meningitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Interleukin-6 measured by electrochemiluminescence method is a promising marker for early differentiation between aseptic and bacterial meningitis. More studies are needed to validate clinical implications for future practice in an emergency laboratory.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0004563215589381","type":"journal-article","created":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T21:31:28Z","timestamp":1431639088000},"page":"155-163","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Interleukin-6 in cerebrospinal fluid as a biomarker of acute meningitis"],"prefix":"10.1177","volume":"53","author":[{"given":"Pablo","family":"Garc\u00eda-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Clinical Biochemistry, Laboratory of Medicine, Hospital Universitario Central de Asturias, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Prieto","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry, Laboratory of Medicine, Hospital Universitario Central de 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