{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:10:57Z","timestamp":1790964657852,"version":"4.1.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T00:00:00Z","timestamp":1435104000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>A middle-aged woman with neutropenia and ataxia was found to have raised plasma zinc and profoundly low plasma copper concentrations. When found that she had been prescribed 135\u2009mg zinc\/day for seven years, a diagnosis of zinc-induced copper deficiency was made. After the zinc prescription was stopped, her copper and zinc concentrations and neutropenia normalized but she only had partial improvement in neurological status. The diagnosis of zinc-induced copper deficiency can be facilitated by the laboratory through measurement of plasma zinc concentration in patients with a low plasma copper concentration.<\/jats:p>","DOI":"10.1177\/0004563215595429","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T21:14:42Z","timestamp":1435266882000},"page":"298-301","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["The role of the clinical biochemist in detection of zinc-induced copper deficiency"],"prefix":"10.1177","volume":"53","author":[{"given":"A","family":"Duncan","sequence":"first","affiliation":[{"name":"Scottish Trace Element and Micronutrient Reference Laboratory, Glasgow Royal Infirmary, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Gallacher","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Hairmyres Hospital, East Kilbride, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Willox","sequence":"additional","affiliation":[{"name":"Scottish Trace Element and Micronutrient Reference Laboratory, Glasgow Royal Infirmary, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,6,24]]},"reference":[{"key":"bibr1-0004563215595429","unstructured":"Food Standards Agency. Eat well, be well, www.eatwellscotland.org\/healthydiet\/nutritionessentials\/vitaminsandminerals\/zinc\/index.html (2010, accessed 14 July 2014)."},{"key":"bibr2-0004563215595429","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1978.03290200066029"},{"key":"bibr3-0004563215595429","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2009.00250.x"},{"key":"bibr4-0004563215595429","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2795(77)90057-5"},{"key":"bibr5-0004563215595429","first-page":"523","volume":"80","author":"Halfdanarson TR","year":"2008","journal-title":"Eur J Gastroent"},{"key":"bibr6-0004563215595429","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5511-x"},{"key":"bibr7-0004563215595429","unstructured":"Opinion of the scientific committee on food on the tolerable upper intake level of zinc, http:\/\/ec.europa.eu\/food\/fs\/sc\/scf\/out177_en.pdf (2003, accessed 12 January 2015)."},{"key":"bibr8-0004563215595429","unstructured":"Guidelines on Food Fortification with Micronutrients.\n                      World Health Organization\n                      , http:\/\/www.who.int\/nutrition\/publications\/micronutrients\/9241594012\/en\/ (2006, accessed 17 December 2014)."},{"key":"bibr9-0004563215595429","unstructured":"Nordberg GF, Fowler BA and Nordberg M.\n                      Handbook on the toxicology of metals\n                      . Elsevier, 2005, p.55."},{"key":"bibr10-0004563215595429","first-page":"129","volume":"169","author":"Irving JA","year":"2003","journal-title":"Can Med Ass J"},{"key":"bibr11-0004563215595429","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-199304000-00001"},{"key":"bibr12-0004563215595429","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/41.2.285"},{"key":"bibr13-0004563215595429","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1978.03290200044019"},{"key":"bibr14-0004563215595429","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12020"},{"key":"bibr15-0004563215595429","doi-asserted-by":"publisher","DOI":"10.1309\/V6GVYW2QTYD5C5PJ"},{"key":"bibr16-0004563215595429","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.9.1303"},{"key":"bibr17-0004563215595429","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000312375.79881.94"},{"key":"bibr18-0004563215595429","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2009.08.008"},{"key":"bibr19-0004563215595429","doi-asserted-by":"publisher","DOI":"10.12968\/denu.2012.39.8.575"},{"key":"bibr20-0004563215595429","doi-asserted-by":"publisher","DOI":"10.1097\/CND.0b013e3181dc34c0"},{"key":"bibr21-0004563215595429","author":"Duncan A","journal-title":"J Clin Pathol"},{"key":"bibr22-0004563215595429","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2007.10.003"},{"key":"bibr23-0004563215595429","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.023812"},{"key":"bibr24-0004563215595429","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22261"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0004563215595429","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0004563215595429","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0004563215595429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:22:21Z","timestamp":1777378941000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0004563215595429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,24]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1177\/0004563215595429"],"URL":"https:\/\/doi.org\/10.1177\/0004563215595429","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,24]]}}}