{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T08:46:31Z","timestamp":1777797991726,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T00:00:00Z","timestamp":1475020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Obesity is associated with a state of systemic inflammation, mediated by adipose tissue-derived cytokines that may also have metabolic effects, including an effect on insulin resistance. The aim of this study was to compare the serum profile of pro- and anti-inflammatory cytokines in obese and non-obese subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 242 subjects who were either overweight or obese (body mass index [BMI]\u2009\u2265\u200925\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) and non-obese subjects (body mass index &lt;25\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), were recruited in Mashhad in northeastern Iran. The concentrations of serum interleukin-1\u03b1, -1\u03b2, -2, -4, -6, -8 and -10 (IL-1\u03b1, IL-1\u03b2, IL-2, IL-4, IL-6, IL-8 and IL-10), were measured in all subjects, together with serum vascular endothelial growth factor, interferon-\u03b3, epidermal growth factor, monocyte chemoattractant protein-1 and tumour necrosis factor-\u03b1.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The groups differed significantly with respect to measures of adiposity and fasted lipid profile. Serum pro-inflammatory cytokines interferon-\u03b3 and interleukin-1\u03b1, and anti-inflammatory cytokines, interleukin-10, and epidermal growth factor were significantly different between obese and non-obese individuals, as was serum high-sensitivity C-reactive protein. Multivariate regression showed that waist circumference was significantly and independently related to serum monocyte chemoattractant protein-1concentrations ( P\u2009=\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite significant differences in several cytokines between the groups, only monocyte chemoattractant protein-1appeared to be independently related to a measure of adiposity in this population sample from Iran.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0004563216629997","type":"journal-article","created":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T20:32:57Z","timestamp":1453235577000},"page":"663-668","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":47,"title":["Cytokine profiles in overweight and obese subjects and normal weight individuals matched for age and gender"],"prefix":"10.1177","volume":"53","author":[{"given":"Maryam","family":"Azizian","sequence":"first","affiliation":[{"name":"Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elahe","family":"Mahdipour","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Reza","family":"Mirhafez","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Shoeibi","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Nematy","sequence":"additional","affiliation":[{"name":"Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Habibollah","family":"Esmaily","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Mashhad University of Medical Sciences, Mashhad, Iran"},{"name":"Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon AA","family":"Ferns","sequence":"additional","affiliation":[{"name":"Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid","family":"Ghayour-Mobarhan","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"},{"name":"Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,9,28]]},"reference":[{"key":"bibr1-0004563216629997","unstructured":"Katz DL, O'Connell M, Yeh M-C, et al. Public health strategies for preventing and controlling overweight and obesity in school and worksite settings: A report on recommendations of the Task Force on Community Preventive Services.\n                      MMWR Morb Mortal Wkly Rep\n                      2005; 7: 1\u201312."},{"key":"bibr2-0004563216629997","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-010-0142-y"},{"key":"bibr3-0004563216629997","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-6-158"},{"key":"bibr4-0004563216629997","first-page":"1","volume":"38","author":"Mirzazadeh A","year":"2009","journal-title":"Iranian J Public Health"},{"key":"bibr5-0004563216629997","first-page":"146","volume":"4","author":"Veghari G","year":"2010","journal-title":"ICRJ"},{"key":"bibr6-0004563216629997","doi-asserted-by":"publisher","DOI":"10.1136\/adc.87.5.388"},{"key":"bibr7-0004563216629997","first-page":"1","volume":"8","author":"Malekzadeh R","year":"2005","journal-title":"Arch Iranian Med"},{"key":"bibr8-0004563216629997","doi-asserted-by":"crossref","unstructured":"Hsieh PS. Obesity-induced adipose tissue inflammation and insulin resistance In: Croniger C (ed.)\n                      Role of the adipocyte in development of type 2 diabetes\n                      . Europe: InTech, 2011, pp.197\u2013214.","DOI":"10.5772\/20561"},{"key":"bibr9-0004563216629997","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn387"},{"key":"bibr10-0004563216629997","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02138"},{"key":"bibr11-0004563216629997","doi-asserted-by":"publisher","DOI":"10.1007\/BF02912883"},{"key":"bibr12-0004563216629997","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-13-123"},{"key":"bibr13-0004563216629997","unstructured":"World Health Organization. BMI classification. 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