{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:27:39Z","timestamp":1777444059386,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T00:00:00Z","timestamp":1475020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Backgrounds<\/jats:title>\n                    <jats:p>Effects of myocardial injury on E-selectin remain unclear. Thus, we investigated the diagnostic value of E-selectin for myocardial injury in paediatric patients with mycoplasma pneumoniae pneumonia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective and blinded clinical study, plasma E-selectin, cardiac troponin I, creatine kinase isoenzyme MB, interleukin-6 and tumor necrosis factor alpha concentrations were measured in paediatric patients with mycoplasma pneumoniae pneumonia (MPP group, n\u2009=\u2009138). The control group comprised 120 healthy children. The definition of cardiac injury was based on cardiac troponin I or CK-MB (with or possibly without abnormal electrocardiogram evidence). Diagnostic value of E-selectin for myocardial injury was determined by analysing receiver operating characteristic curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 138 mycoplasma pneumoniae pneumonia patients, 40 patients were identified with myocardial injury, while 98 patients were identified without myocardial injury. Plasma E-selectin concentrations were: 40.22\u2009\u00b1\u20094.80\u2009ng\/mL, in patients with myocardial injury; 18.55\u2009\u00b1\u20092.16\u2009ng\/mL, in patients without myocardial injury and 12.39\u2009\u00b1\u20093.27\u2009ng\/mL, in healthy children. For the 40 patients identified with myocardial injury, area under the receiver operating characteristic curve value for plasma E-selectin concentrations was 0.945 (95% CI: 0.899\u20130.991), and optimal diagnostic cut-off value was 29.93\u2009ng\/mL (positive likelihood ratio\u2009=\u200972.5).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>E-selectin was shown to be an effective index for myocardial injury in paediatric patients with mycoplasma pneumoniae pneumonia, and its role in other causes of myocardial injury warrants further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0004563216631570","type":"journal-article","created":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T20:08:39Z","timestamp":1454530119000},"page":"49-54","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Role of E-selectin for diagnosing myocardial injury in paediatric patients with mycoplasma pneumoniae pneumonia"],"prefix":"10.1177","volume":"54","author":[{"given":"Ming-Hong","family":"Deng","sequence":"first","affiliation":[{"name":"The Affiliated Shunde Women and Children\u2019s Hospital of Jinan University, Shunde, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Wang","family":"Lin","sequence":"additional","affiliation":[{"name":"The Affiliated Shunde Women and Children\u2019s Hospital of Jinan University, Shunde, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Na","family":"Sun","sequence":"additional","affiliation":[{"name":"The Affiliated Shunde Women and Children\u2019s Hospital of Jinan University, Shunde, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Lin","family":"Zeng","sequence":"additional","affiliation":[{"name":"The Affiliated Shunde Women and Children\u2019s Hospital of Jinan University, Shunde, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Wen","sequence":"additional","affiliation":[{"name":"The Affiliated Shunde Women and Children\u2019s Hospital of Jinan University, Shunde, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,9,28]]},"reference":[{"key":"bibr1-0004563216631570","unstructured":"Saunders M, Gorelick MH. Nelson textbook of pediatrics, 19th ed. 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