{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:26:27Z","timestamp":1790065587212,"version":"4.0.1"},"reference-count":76,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T00:00:00Z","timestamp":1475020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Concerns with pubertal development are common and can cause considerable distress to patients and their carers. Many presentations reflect normal variations of pubertal timing and primarily require reassurance, although patients may opt for interventions. Other presentations need active management to avoid significant adverse effects on growth and psychosocial development. All should undergo careful assessment, particularly as some children or adolescents presenting with abnormalities in pubertal timing may have serious pathology which requires urgent investigations and treatment. This review describes the appropriate investigations and their interpretation for young people presenting with disorders in pubertal timing.<\/jats:p>","DOI":"10.1177\/0004563216668378","type":"journal-article","created":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T20:07:55Z","timestamp":1471982875000},"page":"20-32","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["The investigation of children and adolescents with abnormalities of pubertal timing"],"prefix":"10.1177","volume":"54","author":[{"given":"Christina","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Paediatric Endocrinology, St George\u2019s University Hospitals NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikki","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology, University Hospital Southampton, NHS Foundation Trust, Hampshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Honour","sequence":"additional","affiliation":[{"name":"Institute of Women's Health, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Crowne","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology, Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,9,28]]},"reference":[{"key":"bibr1-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1136\/adc.45.239.13"},{"key":"bibr2-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1136\/adc.51.3.170"},{"key":"bibr3-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1159\/000362414"},{"key":"bibr4-0004563216668378","first-page":"523","volume-title":"Brook\u2019s Clinical pediatric endocrinology","author":"Tetlow LJ","year":"2006","edition":"5"},{"key":"bibr5-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1670"},{"key":"bibr6-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0019"},{"key":"bibr7-0004563216668378","doi-asserted-by":"publisher","DOI":"10.3109\/03014460903049074"},{"key":"bibr8-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1478"},{"key":"bibr9-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2491"},{"key":"bibr10-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2014.12.004"},{"key":"bibr11-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12398"},{"key":"bibr12-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2015-0558"},{"key":"bibr13-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2013.204123"},{"key":"bibr14-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1180"},{"key":"bibr15-0004563216668378","first-page":"193","volume":"123","author":"American College of Obstetricians and Gynecologists","year":"2014","journal-title":"Obstet Gynecol"},{"key":"bibr16-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1598"},{"key":"bibr17-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1569"},{"key":"bibr18-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0720"},{"key":"bibr19-0004563216668378","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2013.18.4.196"},{"key":"bibr20-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1783"},{"key":"bibr21-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1159\/000342342"},{"key":"bibr22-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-67-3-474"},{"key":"bibr23-0004563216668378","first-page":"3408","volume":"81","author":"Rosenfield RL","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"bibr24-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1140"},{"key":"bibr25-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2014.08.009"},{"key":"bibr26-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800094-6.00002-9"},{"key":"bibr27-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1997.t01-1-1150928.x"},{"key":"bibr28-0004563216668378","first-page":"1869","volume":"80","author":"Crowne EC","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"bibr29-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1159\/000327415"},{"key":"bibr30-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-3031"},{"key":"bibr31-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27302012000800012"},{"key":"bibr32-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2014-0295"},{"key":"bibr33-0004563216668378","first-page":"1730","volume":"81","author":"Cai LQ","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"bibr34-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1046\/j.0300-0664.2001.01448.x"},{"key":"bibr35-0004563216668378","first-page":"134","volume":"85","author":"Kubini K","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"bibr36-0004563216668378","first-page":"1634","volume":"85","author":"Sehested A","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"bibr37-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1535"},{"key":"bibr38-0004563216668378","first-page":"CR511","volume":"16","author":"Adan L","year":"2010","journal-title":"Med Sci Monit"},{"key":"bibr39-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12613"},{"key":"bibr40-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2010.08.011"},{"key":"bibr41-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1207"},{"key":"bibr42-0004563216668378","first-page":"627","volume":"84","author":"Rey RA","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"bibr43-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.12.3065"},{"key":"bibr44-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der435"},{"key":"bibr45-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-1621"},{"key":"bibr46-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-3180"},{"key":"bibr47-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu076"},{"key":"bibr48-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2009.11.007"},{"key":"bibr49-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1007\/BF00445660"},{"key":"bibr50-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(98)00044-8"},{"key":"bibr51-0004563216668378","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.v2i1.1"},{"key":"bibr52-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1258\/000456306777695564"},{"key":"bibr53-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1159\/000327417"},{"key":"bibr54-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1159\/000346406"},{"key":"bibr55-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2013.01.002"},{"key":"bibr56-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2015.09.020"},{"key":"bibr57-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-013-0558-1"},{"key":"bibr58-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-1181"},{"key":"bibr59-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1159\/000327415"},{"key":"bibr60-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-1084"},{"key":"bibr61-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(95)00108-C"},{"key":"bibr62-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2009.11.001"},{"key":"bibr63-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.10.043"},{"key":"bibr64-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24825"},{"key":"bibr65-0004563216668378","first-page":"1","volume":"8","author":"Faizah M","year":"2012","journal-title":"Biomed Imaging Interv J"},{"key":"bibr66-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2000.13.S1.695"},{"key":"bibr67-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00328-7"},{"key":"bibr68-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2702"},{"key":"bibr69-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029829"},{"key":"bibr70-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.21.6.g01nv041393"},{"key":"bibr71-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1159\/000323361"},{"key":"bibr72-0004563216668378","first-page":"96","volume-title":"Brook\u2019s clinical pediatric endocrinology","author":"Patel L","year":"2006","edition":"5"},{"key":"bibr73-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1530\/JME-14-0315"},{"key":"bibr74-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2011.68"},{"key":"bibr75-0004563216668378","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031225"},{"key":"bibr76-0004563216668378","first-page":"77","volume":"3","author":"Reiter EO","year":"2005","journal-title":"Pediatr Endocrinol Rev"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0004563216668378","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0004563216668378","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0004563216668378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:22:56Z","timestamp":1777378976000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0004563216668378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,28]]},"references-count":76,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1177\/0004563216668378"],"URL":"https:\/\/doi.org\/10.1177\/0004563216668378","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,28]]}}}