{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:13:31Z","timestamp":1793643211392,"version":"4.5.1"},"reference-count":15,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T00:00:00Z","timestamp":1475020800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>\n                    In this study, we present a case of falsely elevated oestradiol (E\n                    <jats:sub>2<\/jats:sub>\n                    ) concentration, determined by two immunoassays, in a breast cancer patient receiving exemestane therapy. The positive bias of immunochemical measurements was revealed using liquid chromatography tandem mass spectrometry which showed undetectable E\n                    <jats:sub>2<\/jats:sub>\n                    concentration. The discrepancy is expected to be a consequence of the structural resemblance of E\n                    <jats:sub>2<\/jats:sub>\n                    and exemestane sharing the same steroidal backbone. Inaccurate laboratory findings in therapy monitoring, as in this case, may lead to unnecessary changes of therapy.\n                  <\/jats:p>","DOI":"10.1177\/0004563216674031","type":"journal-article","created":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T20:08:01Z","timestamp":1475179681000},"page":"402-405","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Falsely elevated serum oestradiol due to exemestane therapy"],"prefix":"10.1177","volume":"54","author":[{"given":"Sanja","family":"Mandic","sequence":"first","affiliation":[{"name":"Institute of Clinical Laboratory Diagnostics, Osijek University Hospital, Osijek, Croatia"},{"name":"Department for Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine, University of Osijek, Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u03cbrgen","family":"Kratzsch","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Clinic Leipzig-A\u00d6R, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Mandic","sequence":"additional","affiliation":[{"name":"Institute of Clinical Laboratory Diagnostics, Osijek University Hospital, Osijek, Croatia"},{"name":"Department for Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine, University of Osijek, Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeljko","family":"Debeljak","sequence":"additional","affiliation":[{"name":"Institute of Clinical Laboratory Diagnostics, Osijek University Hospital, Osijek, Croatia"},{"name":"Department of Pharmacology, Faculty of Medicine, University of Osijek, Osijek, 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