{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:13:27Z","timestamp":1793726007887,"version":"4.6.1"},"reference-count":26,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T00:00:00Z","timestamp":1484179200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>Kawasaki disease is a febrile disease of childhood that is associated with increased inflammatory cytokines and immunoregulatory abnormalities. While the serum concentrations of soluble IL-2 receptor can change under such pathologies, the relevance of the soluble IL-2 receptor concentration in patients with Kawasaki disease has not been specified. We aimed to summarize the existing studies that reported the soluble IL-2 receptor concentrations in patients with Kawasaki disease. Original articles that were published up to July 2016 were collected using a PubMed\/Medline-based search engine. A total of nine articles that reported the serum soluble IL-2 receptor concentrations in acute-phase Kawasaki disease were eligible. All of the articles described a high soluble IL-2 receptor concentration in patients with Kawasaki disease relative to the level of controls or the reference range. Two of five articles on patients with coronary artery aneurysms described a significantly higher soluble IL-2 receptor concentration in patients with coronary artery aneurysms than patients without. Two articles on patients with intravenous immunoglobulin therapy described a significant decrease of the soluble IL-2 receptor concentration after the therapy. Accordingly, the serum soluble IL-2 receptor can be a potent marker of disease activity and therapeutic effects in patients with Kawasaki disease; further studies are thus warranted for its use in the clinical setting.<\/jats:p>","DOI":"10.1177\/0004563216677583","type":"journal-article","created":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T20:07:49Z","timestamp":1477426069000},"page":"209-213","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["The serum concentration of soluble interleukin-2 receptor in patients with Kawasaki disease"],"prefix":"10.1177","volume":"54","author":[{"given":"Hiroyuki","family":"Teraura","sequence":"first","affiliation":[{"name":"Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, Tochigi, Japan"},{"name":"Department of Medicine, Iwate Prefectural Senmaya Hospital, Iwate, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Kotani","sequence":"additional","affiliation":[{"name":"Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, Tochigi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaomi","family":"Minami","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jichi Medical University, Tochigi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Takeshima","sequence":"additional","affiliation":[{"name":"Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, Tochigi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Shimooki","sequence":"additional","affiliation":[{"name":"Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, Tochigi, Japan"},{"name":"Department of Medicine, Iwate Prefectural Senmaya Hospital, Iwate, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Kajii","sequence":"additional","affiliation":[{"name":"Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, Tochigi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,1,12]]},"reference":[{"key":"bibr1-0004563216677583","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1542\/peds.54.3.271","volume":"54","author":"Kawasaki T","year":"1973","journal-title":"Pediatrics"},{"key":"bibr2-0004563216677583","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20140089"},{"key":"bibr3-0004563216677583","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-307536"},{"key":"bibr4-0004563216677583","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.12.073"},{"key":"bibr5-0004563216677583","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(90)90166-N"},{"key":"bibr6-0004563216677583","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.1992.33.2.183"},{"key":"bibr7-0004563216677583","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2010.03163.x"},{"key":"bibr8-0004563216677583","first-page":"244","volume":"97","author":"Yamamoto J","year":"2009","journal-title":"Diagn Treat"},{"key":"bibr9-0004563216677583","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2006.07.003"},{"key":"bibr10-0004563216677583","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"},{"key":"bibr11-0004563216677583","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.228.351"},{"key":"bibr12-0004563216677583","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.52.141"},{"key":"bibr13-0004563216677583","first-page":"49","volume":"38","author":"Matsubara T","year":"1989","journal-title":"Allergy"},{"key":"bibr14-0004563216677583","doi-asserted-by":"publisher","DOI":"10.1007\/BF02009673"},{"key":"bibr15-0004563216677583","doi-asserted-by":"publisher","DOI":"10.1007\/BF01956740"},{"key":"bibr16-0004563216677583","first-page":"208","volume":"8","author":"Peng Q","year":"2006","journal-title":"Chinese J Contem Pediatr"},{"key":"bibr17-0004563216677583","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81610-5"},{"key":"bibr18-0004563216677583","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330909"},{"key":"bibr19-0004563216677583","doi-asserted-by":"publisher","DOI":"10.1006\/clim.2001.5026"},{"key":"bibr20-0004563216677583","first-page":"109","volume":"34","author":"Minami T","year":"2011","journal-title":"Jichi Med Univ J"},{"key":"bibr21-0004563216677583","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318220c3cf"},{"key":"bibr22-0004563216677583","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.02.048"},{"key":"bibr23-0004563216677583","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12182"},{"key":"bibr24-0004563216677583","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61930-2"},{"key":"bibr25-0004563216677583","first-page":"120","volume":"27","author":"Alenius GM","year":"2009","journal-title":"Clin Exp Rheumatol"},{"key":"bibr26-0004563216677583","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/36.2.190"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0004563216677583","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0004563216677583","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0004563216677583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:23:01Z","timestamp":1777378981000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0004563216677583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,12]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1177\/0004563216677583"],"URL":"https:\/\/doi.org\/10.1177\/0004563216677583","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,12]]}}}