{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:30:59Z","timestamp":1777444259267,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T00:00:00Z","timestamp":1498694400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Non-invasive methods for assessing liver fibrosis are increasingly used as an alternative to liver biopsy. Recently, a score-based biochemical blood test (Coopscore\n                      <jats:sup>\u00a9<\/jats:sup>\n                      ) was developed in a cohort of patients chronically infected with hepatitis C virus, showing higher diagnostic performances than Fibrometer\u00ae, Fibrotest\u00ae, Hepascore\u00ae and Fibroscan\u2122. Here, we assess its performance in patients co-infected with the human immunodeficiency virus and hepatitis B virus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Ninety-seven human immunodeficiency virus\/hepatitis B virus co-infected patients with liver biopsies were included from a previously described cohort. Histological fibrosis staging using METAVIR criteria was used as the reference. Coopscore\n                      <jats:sup>\u00a9<\/jats:sup>\n                      , Fibrotest\u00ae, Fibrometer\u00ae, Hepascore\u00ae and Zeng score were computed and compared with the Coopscore\u00a9 using the Obuchowski index and area under the receiving operator characteristic curves.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The distribution of liver fibrosis levels was as follows: F0\u2013F1 ( n\u2009=\u200942), F2 ( n\u2009=\u200925), F3 ( n\u2009=\u200915) and F4 ( n\u2009=\u200915). The Obuchowski index was higher for Coopscore\n                      <jats:sup>\u00a9<\/jats:sup>\n                      (0.774) than Fibrometer\u00ae (0.668), Hepascore\u00ae (0.690) and Zeng scores (0.704) ( P\u2009&lt;\u20090.05), reflecting a better ability to discriminate between fibrosis stages. Similarly, when predicting significant fibrosis (\u2265F2), the AUROC was significantly greater for the Coopscore\n                      <jats:sup>\u00a9<\/jats:sup>\n                      (0.836) than the Hepascore\u00ae (0.727) and Zeng scores (0.746), but not for the Fibrotest\u00ae (0.778, P\u2009=\u20090.14) or Fibrometer\u00ae (0.790, P\u2009=\u20090.19). The Coopscore\n                      <jats:sup>\u00a9<\/jats:sup>\n                      did not show a higher capacity than other scores to predict advanced fibrosis (\u2265F3) or cirrhosis (F4).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study supports the diagnostic value of the Coospcore\n                      <jats:sup>\u00a9<\/jats:sup>\n                      in fibrosis staging among human immunodeficiency virus\/hepatitis B virus co-infected patients, especially to predict significant fibrosis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0004563217707979","type":"journal-article","created":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T10:10:29Z","timestamp":1526983829000},"page":"236-243","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Diagnostic accuracy of the Coopscore\n                    <sup>\u00a9<\/sup>\n                    to predict liver fibrosis in human immunodeficiency virus\/hepatitis B virus co-infection"],"prefix":"10.1177","volume":"55","author":[{"given":"Ludmia","family":"Taibi","sequence":"first","affiliation":[{"name":"P\u00f4le de Biologie M\u00e9dicale et Pathologie, H\u00f4pitaux Universitaire de l\u2019Est Parisien, site Saint-Antoine, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Boyd","sequence":"additional","affiliation":[{"name":"INSERM, UMR_S1136, Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelly","family":"Bosselut","sequence":"additional","affiliation":[{"name":"P\u00f4le de Biologie M\u00e9dicale et Pathologie, H\u00f4pitaux Universitaire de l\u2019Est Parisien, site Saint-Antoine, Paris, France"},{"name":"INSERM, UMR-S 938, F-75012, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Bottero","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et Tropicales, H\u00f4pital Saint-Antoine, AP-HP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Gu\u00e9chot","sequence":"additional","affiliation":[{"name":"P\u00f4le de Biologie M\u00e9dicale et Pathologie, H\u00f4pitaux Universitaire de l\u2019Est Parisien, site Saint-Antoine, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine","family":"Lacombe","sequence":"additional","affiliation":[{"name":"INSERM, UMR_S1136, Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique, Paris, France"},{"name":"Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique, Sorbonne Universit\u00e9s, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Lasnier","sequence":"additional","affiliation":[{"name":"P\u00f4le de Biologie M\u00e9dicale et Pathologie, H\u00f4pitaux Universitaire de l\u2019Est Parisien, site Saint-Antoine, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Baudin","sequence":"additional","affiliation":[{"name":"P\u00f4le de Biologie M\u00e9dicale et Pathologie, H\u00f4pitaux Universitaire de l\u2019Est Parisien, site Saint-Antoine, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Vaubourdolle","sequence":"additional","affiliation":[{"name":"P\u00f4le de Biologie M\u00e9dicale et Pathologie, H\u00f4pitaux Universitaire de l\u2019Est Parisien, site Saint-Antoine, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,6,29]]},"reference":[{"key":"bibr1-0004563217707979","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2009.01249.x"},{"key":"bibr2-0004563217707979","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25800"},{"key":"bibr3-0004563217707979","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1630"},{"key":"bibr4-0004563217707979","doi-asserted-by":"crossref","unstructured":"Boyd A, Bottero J, Miailhes P, et\u00a0al. 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