{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:31:59Z","timestamp":1777444319931,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T00:00:00Z","timestamp":1511395200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is interest in utilizing different cut-offs per sex for high-sensitivity cardiac troponin I (hs-cTnI) but less so for high-sensitivity cardiac troponin T (hs-cTnT) for patient management in the acute setting. Our objective was to assess if differences in hs-cTn concentrations exist between males and females for an acute cardiac outcome following the presentation measurement in the emergency department.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An observational emergency department population with hs-cTn measurements (Roche Diagnostics and Abbott Diagnostics) at presentation with seven-day outcomes for a composite acute cardiac outcome (i.e. myocardial infarction, unstable angina, ventricular arrhythmia, heart failure or cardiovascular death) (ClinicalTrials.gov: NCT01994577). Receiver operating characteristic curve analyses were performed for each sex with both hs-cTn assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In those patients who had a composite acute cardiac outcome ( n\u2009=\u2009128 females; n\u2009=\u2009145 males), there was no difference in hs-cTn concentrations between the sexes (median [IQR] female hs-cTnT\u2009=\u200935\u2009ng\/L [21\u201369] vs. male hs-cTnT\u2009=\u200938\u2009ng\/L [19\u201377], P\u2009=\u20090.95; and median [IQR] female hs-cTnI\u2009=\u200927\u2009ng\/L [12\u201375] vs. male hs-cTnI\u2009=\u200926\u2009ng\/L [12\u201385], P\u2009=\u20090.97]. There was also no difference in the area under the curve between the hs-cTn assays and between the sexes ( P\u2009&gt;\u20090.10). Comparing hs-cTn concentrations in those patients with the composite outcome between the sexes &lt;60 years and \u226560 years of age also did not yield significant differences ( P\u2009&gt;\u20090.70).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The concentrations and area under the curves of hs-cTnT and hs-cTnI at patient presentation in the emergency department for an acute composite cardiac outcome were similar between the sexes in this exploratory study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0004563217743997","type":"journal-article","created":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T10:28:03Z","timestamp":1534760883000},"page":"604-607","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["High-sensitivity cardiac troponin concentrations at emergency department presentation in females and males with an acute cardiac outcome"],"prefix":"10.1177","volume":"55","author":[{"given":"Peter A","family":"Kavsak","sequence":"first","affiliation":[{"name":"Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Worster","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine, McMaster University, Hamilton, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colleen","family":"Shortt","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhui","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Clayton","sequence":"additional","affiliation":[{"name":"Department of Medicine, McMaster University, Hamilton, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Sherbino","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine, McMaster University, Hamilton, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen A","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"McQueen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Griffith","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shamir R","family":"Mehta","sequence":"additional","affiliation":[{"name":"Division of Cardiology, and Population Health Research Institute, McMaster University, Hamilton, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PJ","family":"Devereaux","sequence":"additional","affiliation":[{"name":"Division of Cardiology, and Population Health Research Institute, McMaster University, Hamilton, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,11,23]]},"reference":[{"key":"bibr1-0004563217743997","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw232"},{"key":"bibr2-0004563217743997","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7873"},{"key":"bibr3-0004563217743997","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.2882"},{"key":"bibr4-0004563217743997","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2016.261545"},{"key":"bibr5-0004563217743997","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2017.04.011"},{"key":"bibr6-0004563217743997","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2017.03.021"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0004563217743997","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0004563217743997","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0004563217743997","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:23:23Z","timestamp":1777379003000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/0004563217743997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,23]]},"references-count":6,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1177\/0004563217743997"],"URL":"https:\/\/doi.org\/10.1177\/0004563217743997","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,23]]}}}