{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:32:15Z","timestamp":1777444335597,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T00:00:00Z","timestamp":1517270400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We investigated the percentage of patients diagnosed with the correct underlying cause of anaemia by general practitioners when using an extensive versus a routine laboratory work-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An online survey was distributed among 836 general practitioners. The survey consisted of six cases, selected from an existing cohort of anaemia patients ( n\u2009=\u20093325). In three cases, general practitioners were asked to select the laboratory tests for further diagnostic examination from a list of 14 parameters (i.e. routine work-up). In the other three cases, general practitioners were presented with all 14 laboratory test results available (i.e. extensive work-up). General practitioners were asked to determine the underlying cause of anaemia in all six cases based on the test results, and these answers were compared with the answers of an expert panel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 139 general practitioners (partly) responded to the survey (17%). The general practitioners were able to determine the underlying cause of anaemia in 53% of cases based on the routine work-up, whereas 62% of cases could be diagnosed using an extensive work-up ( P\u2009=\u20090.007). In addition, the probability of a correct diagnosis decreased with the patient\u2019s age and was also affected by the underlying cause itself, with anaemia of chronic disease being hardest to diagnose ( P\u2009=\u20090.003).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The use of an extensive laboratory work-up in patients with newly diagnosed anaemia is expected to increase the percentage of correct underlying causes established by general practitioners. Since the underlying cause can still not be established in 31.3% of anaemia patients, further research is necessary.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0004563217748680","type":"journal-article","created":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T10:28:03Z","timestamp":1534760883000},"page":"535-542","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["The effectiveness of a routine versus an extensive laboratory analysis in the diagnosis of anaemia in general practice"],"prefix":"10.1177","volume":"55","author":[{"given":"Annemarie","family":"Schop","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6405-6789","authenticated-orcid":false,"given":"Michelle MA","family":"Kip","sequence":"additional","affiliation":[{"name":"Department of Health Technology and Services Research, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karlijn","family":"Stouten","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Albert Schweitzer Hospital, Dordrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soraya","family":"Dekker","sequence":"additional","affiliation":[{"name":"Department of Health Technology and Services Research, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jurgen","family":"Riedl","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Albert Schweitzer Hospital, Dordrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron J","family":"van Houten","sequence":"additional","affiliation":[{"name":"General Medical Practice van Houten, Hendrik-Ido-Ambacht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9187-244X","authenticated-orcid":false,"given":"Joost","family":"van Rosmalen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Erasmus MC, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geert-Jan","family":"Dinant","sequence":"additional","affiliation":[{"name":"Department of General Practice, Caphri School for Public Health and Primary Care, Maastricht University, Maastricht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten J","family":"IJzerman","sequence":"additional","affiliation":[{"name":"Department of Health Technology and Services Research, MIRA 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