{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:13:03Z","timestamp":1791969183079,"version":"4.3.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T00:00:00Z","timestamp":1531872000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Key Technologies of Prevention and Control for Major and Infectious Diseases","award":["GWZX201604"],"award-info":[{"award-number":["GWZX201604"]}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20171147"],"award-info":[{"award-number":["BK20171147"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Projects of Wuxi City","award":["YGZXM1501"],"award-info":[{"award-number":["YGZXM1501"]}]},{"name":"Science and Technology Projects of Wuxi City","award":["Q201701"],"award-info":[{"award-number":["Q201701"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Serum YKL-40 has been proved to be a promising biomarker for estimating the disease activity of several autoimmune diseases. However, its utility in polymyositis or dermatomyositis has not been established. The aim of this study was to investigate the utility of YKL-40 in patients with polymyositis\/dermatomyositis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Patients with definite polymyositis\/dermatomyositis who visited the Second People\u2019s Hospital of Wuxi between April 2016 and March 2017 were prospectively enrolled. Eighty-seven healthy individuals were set as a control. Serum YKL-40 of all participants was determined using ELISA. The associations between YKL-40 and clinical characteristics of polymyositis\/dermatomyositis were analysed using the Student\u2019s t-test, Mann-Whitney test and receiver operating characteristic curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 99 patients with polymyositis\/dermatomyositis were enrolled. The patients with polymyositis\/dermatomyositis had significantly higher serum YKL-40 concentration. Patients with interstitial lung disease had significantly higher YKL-40 concentration than those without. Serum YKL-40 was positively correlated with myositis disease activity assessment visual analogue scale, C-reactive protein, erythrocyte sedimentation rate and ferritin. The area under receiver operating characteristic curve of YKL-40 for identifying interstitial lung disease was 0.82.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Serum YKL-40 is a useful biomarker for estimating disease activity or severity of polymyositis\/dermatomyositis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0004563218786979","type":"journal-article","created":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T14:46:53Z","timestamp":1531925213000},"page":"95-99","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Elevated serum YKL-40 correlates with clinical characteristics in patients with polymyositis or dermatomyositis"],"prefix":"10.1177","volume":"56","author":[{"given":"Ming-Zhu","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Wuxi Second People\u2019s Hospital of Nanjing Medical University, Wuxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Yu","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Wuxi Second People\u2019s Hospital of Nanjing Medical University, Wuxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang-Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Wuxi Second People\u2019s Hospital of Nanjing Medical University, Wuxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Wuxi Second People\u2019s Hospital of Nanjing Medical University, Wuxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Jun","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Wuxi Second People\u2019s Hospital of Nanjing Medical University, Wuxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Wang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Institution for Laboratory Medicine, Changshu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,7,18]]},"reference":[{"key":"bibr1-0004563218786979","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24566"},{"key":"bibr2-0004563218786979","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket279"},{"key":"bibr3-0004563218786979","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2011.01.002"},{"key":"bibr4-0004563218786979","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.06.007"},{"key":"bibr5-0004563218786979","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes167"},{"key":"bibr6-0004563218786979","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0562-9"},{"key":"bibr7-0004563218786979","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.13.124"},{"key":"bibr8-0004563218786979","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3347-1"},{"key":"bibr9-0004563218786979","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.141307"},{"key":"bibr10-0004563218786979","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14368-1"},{"key":"bibr11-0004563218786979","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1997.3764"},{"key":"bibr12-0004563218786979","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)74461-5"},{"key":"bibr13-0004563218786979","first-page":"5","volume":"51","author":"Kazakova MH","year":"2009","journal-title":"Folia Med (Plovdiv)"},{"key":"bibr14-0004563218786979","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.10.58"},{"key":"bibr15-0004563218786979","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2011.04.007"},{"key":"bibr16-0004563218786979","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.7.544"},{"key":"bibr17-0004563218786979","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2002.004408"},{"key":"bibr18-0004563218786979","doi-asserted-by":"crossref","first-page":"777","DOI":"10.20452\/pamw.839","volume":"119","author":"Wcislo-Dziadecka D","year":"2009","journal-title":"Pol Arch Med Wewn"},{"key":"bibr19-0004563218786979","doi-asserted-by":"publisher","DOI":"10.1080\/030097401753180381"},{"key":"bibr20-0004563218786979","first-page":"655","volume":"19","author":"Matsumoto T","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"bibr21-0004563218786979","doi-asserted-by":"crossref","unstructured":"Committee of the American Rheumatism Association. 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