{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:35:25Z","timestamp":1777444525395,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T00:00:00Z","timestamp":1572825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Gynaecomastia is a common finding which typically appears during puberty in boys and in elderly males. At these times, gynaecomastia is likely to be due to physiological hormonal fluctuations, although there are a number of other causes including medications which must also be considered. We present a case of a 52-year-old male with gynaecomastia, hypogonadotropic hypogonadism and hyperoestrogenaemia. MRI of the adrenals confirmed the presence of an adrenocortical carcinoma, which after preoperative hormone workup was diagnosed as a feminizing adrenal tumour. The lesion was excised, and adjunct Mitotane therapy was commenced. Hyperoestrogenaemia is often secondary to exogenous testosterone administration; however, in the presence of hypogonadotropic hypogonadism, other sources of oestrogen should be sought. This case highlights a rare, but nonetheless important cause of gynaecomastia.<\/jats:p>","DOI":"10.1177\/0004563219884960","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T12:26:59Z","timestamp":1570710419000},"page":"99-101","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Gynaecomastia caused by a feminizing adrenal tumour"],"prefix":"10.1177","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9247-6705","authenticated-orcid":false,"given":"Stephen M","family":"Gibbons","sequence":"first","affiliation":[{"name":"SAS Steroid Centre, Specialist Laboratory Medicine, St James University Hospital, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuthar","family":"Jassam","sequence":"additional","affiliation":[{"name":"Biochemistry, Harrogate District Hospital, Harrogate, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afroze","family":"Abbas","sequence":"additional","affiliation":[{"name":"Endocrinology, Saint James University Hospital, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Stuart","sequence":"additional","affiliation":[{"name":"SAS Steroid Centre, Specialist Laboratory Medicine, St James University Hospital, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"April","family":"Fairhurst","sequence":"additional","affiliation":[{"name":"SAS Steroid Centre, Specialist Laboratory Medicine, St James University Hospital, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian H","family":"Barth","sequence":"additional","affiliation":[{"name":"SAS Steroid Centre, Specialist Laboratory Medicine, St James University Hospital, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,11,4]]},"reference":[{"key":"bibr1-0004563219884960","unstructured":"Swerdloff R, Ng CM. Gynecomastia: etiology, diagnosis, and treatment. In: Feingold KR, Anawalt B, Boyce A, et\u00a0al. (eds)\n                      Endotext\n                      . South Dartmouth (MA): MDText.com, Inc. 2015, pp. 2000\u20132002."},{"key":"bibr2-0004563219884960","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2015.00045"},{"key":"bibr3-0004563219884960","doi-asserted-by":"publisher","DOI":"10.1210\/er.2013-1029"},{"key":"bibr4-0004563219884960","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-18-0608"},{"key":"bibr5-0004563219884960","first-page":"145","volume":"7","author":"Johnson RE","year":"2011","journal-title":"Ther Clin Risk Manag"},{"key":"bibr6-0004563219884960","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/51.5.798"},{"key":"bibr7-0004563219884960","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-1147"},{"key":"bibr8-0004563219884960","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.111669"},{"key":"bibr9-0004563219884960","doi-asserted-by":"publisher","DOI":"10.1007\/BF03348975"},{"key":"bibr10-0004563219884960","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-02591"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0004563219884960","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0004563219884960","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0004563219884960","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:24:02Z","timestamp":1777379042000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0004563219884960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,4]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1177\/0004563219884960"],"URL":"https:\/\/doi.org\/10.1177\/0004563219884960","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,4]]}}}