{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:40:56Z","timestamp":1780504856984,"version":"3.54.1"},"reference-count":9,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:00:00Z","timestamp":1587945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Plasma viscosity is an important biomarker both in diagnostics and treatment monitoring of plasma cell dyscrasias and other disorders with hyperviscosity syndrome as a clinical manifestation. Here, we investigate the performance of a new microfluidic-based viscometer for clinical use, establish a new reference range to be used with this instrument and determine the importance of sampling temperature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The microVisc\u2122 viscometer was evaluated for within-run and between-run imprecision and bias using standardized reference material (Paragon controls) and Seronorm\u2122 control material. The reference range was established for the adult population using EDTA-plasma from 120 healthy blood donors. Sampling temperature was investigated by drawing and transporting blood at room temperature and 37\u00b0C and comparing the viscosity between the two sampling methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The microfluidic-based viscometer performed well, and imprecision was comparable to ReoRox\u00ae G2 free oscillation rheometer. A new reference range for the adult Danish population was established as 1.2\u20131.5 mPa s at 37\u00b0C. Furthermore, sampling temperature at room temperature and 37\u00b0C was investigated, and there was no difference in results obtained.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MicroVisc\u2122 is suitable for measuring plasma viscosity in a clinical setting and results can be evaluated using the established reference range. Blood sampling for viscosity analysis can be performed as a standard procedure at room temperature.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0004563220920903","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T21:08:02Z","timestamp":1586207282000},"page":"249-252","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Plasma viscosity: Evaluation of a new measuring method using microfluidic chip technology (microVisc\u2122) for clinical use and determination of a new reference range"],"prefix":"10.1177","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9982-1236","authenticated-orcid":false,"given":"Louise H","family":"J\u00f8rgensen","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark"},{"name":"Institute of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivi S","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Revsholm","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,4,27]]},"reference":[{"key":"bibr1-0004563220920903","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(85)90540-6"},{"key":"bibr2-0004563220920903","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108568"},{"key":"bibr3-0004563220920903","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-44554"},{"key":"bibr4-0004563220920903","first-page":"S78","volume":"125","author":"Rosencranz R","year":"2006","journal-title":"Am J Clin Pathol"},{"key":"bibr5-0004563220920903","volume-title":"The revolutionary portable & fast viscometer","author":"microVISC\u2122 User\u2019s manual.","edition":"1"},{"key":"bibr6-0004563220920903","unstructured":"Transfusion Medical Standards. Version 5.0. \u00a9 1994-2019 Danish Society for Clinical Immunology, July 2019."},{"key":"bibr7-0004563220920903","doi-asserted-by":"publisher","DOI":"10.3233\/CH-2008-1088"},{"key":"bibr8-0004563220920903","doi-asserted-by":"publisher","DOI":"10.1177\/0004563213504550"},{"key":"bibr9-0004563220920903","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.37.10.1147"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0004563220920903","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0004563220920903","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0004563220920903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:24:07Z","timestamp":1777379047000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0004563220920903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,27]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1177\/0004563220920903"],"URL":"https:\/\/doi.org\/10.1177\/0004563220920903","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,27]]}}}