{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T06:13:01Z","timestamp":1793167981204,"version":"4.5.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    Chronic diarrhoea is common and mostly due to diarrhoea predominant irritable bowel syndrome. Diarrhoea predominant irritable bowel syndrome affects about 11% of the population; however, up to a third of these patients actually have bile acid diarrhoea. There are, therefore, more than one million sufferers of bile acid diarrhoea in the UK. Bile acid diarrhoea is caused by small bowel malabsorption of bile acids and the increased bile acids in the large intestine cause diarrhoea. Once diagnosed, the treatment of bile acid diarrhoea is simple and effective. Bile acid diarrhoea , however, is often not diagnosed because of a lack of easily available and reliable diagnostic methods. In the United Kingdom, the radiolabelled 23-seleno-25-homotaurocholic acid test is the gold-standard method of diagnosis. 23-seleno-25-homotaurocholic acid test, however, is expensive, inconvenient to the patient, involves radiation exposure and has limited availability. As such, a laboratory biomarker is desirable. This review briefly discusses the pathophysiology and management of bile acid diarrhoea and critically evaluates methods for its diagnosis, including serum 7\u03b1-hydroxy-4-cholesten-3-one, faecal bile acid measurement, serum fibroblast growth factor 19, urine-2-propanol, and the\n                    <jats:sup>14<\/jats:sup>\n                    C-glycocholate breath and stool test.\n                  <\/jats:p>","DOI":"10.1177\/0004563220966139","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:24:22Z","timestamp":1601511862000},"page":"22-28","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Bile acid diarrhoea: Current and potential methods of diagnosis"],"prefix":"10.1177","volume":"58","author":[{"given":"Lauren E","family":"Hughes","sequence":"first","affiliation":[{"name":"Clinical Chemistry, Royal Wolverhampton NHS Trust, Wolverhampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Ford","sequence":"additional","affiliation":[{"name":"Clinical Chemistry, Royal Wolverhampton NHS Trust, Wolverhampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J","family":"Brookes","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Royal Wolverhampton NHS Trust, Wolverhampton, UK"},{"name":"Faculty of Education, Health and Wellbeing, University of Wolverhampton, Wolverhampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7483-9253","authenticated-orcid":false,"given":"Rousseau","family":"Gama","sequence":"additional","affiliation":[{"name":"Clinical Chemistry, Royal Wolverhampton NHS Trust, Wolverhampton, UK"},{"name":"School of Medicine and Clinical Practice, Wolverhampton University, Wolverhampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"bibr1-0004563220966139","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.02.029"},{"key":"bibr2-0004563220966139","first-page":"158","volume":"28","author":"Endo Y","year":"2015","journal-title":"Ann Gastroenterol"},{"key":"bibr3-0004563220966139","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-12-104"},{"key":"bibr4-0004563220966139","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X10377126"},{"key":"bibr5-0004563220966139","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.215"},{"key":"bibr6-0004563220966139","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13227"},{"key":"bibr7-0004563220966139","doi-asserted-by":"publisher","DOI":"10.5009\/gnl14397"},{"key":"bibr8-0004563220966139","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.72.121801.161712"},{"key":"bibr9-0004563220966139","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22627"},{"key":"bibr10-0004563220966139","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.12449.1"},{"key":"bibr11-0004563220966139","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1002\/cphy.c120023","volume":"3","author":"Chiang JY.","year":"2013","journal-title":"Compr Physiol"},{"key":"bibr12-0004563220966139","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-7568-6"},{"key":"bibr13-0004563220966139","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/485631"},{"key":"bibr14-0004563220966139","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)43096-2"},{"key":"bibr15-0004563220966139","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldp032"},{"key":"bibr16-0004563220966139","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R900012-JLR200"},{"key":"bibr17-0004563220966139","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.09.001"},{"key":"bibr18-0004563220966139","volume-title":"Tietz textbook of clinical chemistry and molecular diagnostics","author":"Burtis CA","year":"2012","edition":"5"},{"key":"bibr19-0004563220966139","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119355"},{"key":"bibr20-0004563220966139","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.04.024"},{"key":"bibr21-0004563220966139","unstructured":"NICE. 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